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| Diet Rich in Saturated Fat Decreases the Ratio of Thromboxane／prostacyclin in Healthy Men^1 | |
| 引用本文： | Li D,Habito R,Angelos G,Sinclair AJ,Ball MJ. Diet Rich in Saturated Fat Decreases the Ratio of Thromboxane／prostacyclin in Healthy Men^1[J]. Biomedical and environmental sciences : BES, 2003, 16(4): 333-339 |
| 作者姓名： | Li D Habito R Angelos G Sinclair AJ Ball MJ |
| 作者单位： | [1]DepartmentofFoodScience,HangzhouUniversityofCommerce,Hangzhou310035,Zhejiang,China [2]DepartmentofBiomedicalScience,UniversityofTasmania,TAS,Australia [3]9epartmentofFoodScience,RMITUniversity,Melbourne,V1C,Australia |
| 摘 要： | Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion ll-dehydro thromboxane B2 (TXB2) and 6-keto prostaglandin F la (PGF la) in 27healthy free-living male subjects aged 30 to 55 years. |
| 关 键 词： | 血栓 动脉硬化 高血脂症 凝血恶烷A2 前列腺素I2 饱和脂肪酸 SFA 发病机理 免疫血清学 TXA2 TXB2 |
Diet rich in saturated fat decreases the ratio of thromboxane/prostacyclin in healthy men |
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| Li Duo,Habito Raymundo,Angelos George,Sinclair Andrew J,Ball Madeleine J. Diet rich in saturated fat decreases the ratio of thromboxane/prostacyclin in healthy men[J]. Biomedical and environmental sciences : BES, 2003, 16(4): 333-339 | |
| Authors: | Li Duo Habito Raymundo Angelos George Sinclair Andrew J Ball Madeleine J |
| Affiliation: | Department of Food Science, Hangzhou University of Commerce, Hangzhou 310035, Zhejiang, China. duoli@mail.hzic.edu.au |
| Abstract: | OBJECTIVE: To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane B2 (TXB2) and 6-keto prostaglandin F 1alpha (PGF 1alpha) in 27 healthy free-living male subjects aged 30 to 55 years. METHODS: It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a 'wash-out period', before being assigned to the other diet for an additional 4 weeks. RESULTS: Serum proportion of 20:4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB2 to 6-keto PGF 1alpha (P < 0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB2. CONCLUSIONS: Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6. |
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