Cell therapy plus transmyocardial laser revascularization for refractory angina |
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| Authors: | Gowdak Luís Henrique W Schettert Isolmar T Rochitte Carlos Eduardo Lisboa Luiz Augusto F Dallan Luís Alberto O César Luiz Antônio M Krieger José Eduardo Ramires José Antônio F Oliveira Sérgio A de |
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| Affiliation: | Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil |
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| Abstract: | We describe the use of autologous bone marrow cells combined with transmyocardial laser revascularization in a 74-year-old man with refractory angina. Baseline cardiac magnetic resonance imaging revealed a markedly depressed left ventricle systolic function and an extensive area of myocardial ischemia. During surgery, 11 laser shots using a CO2 Heart Laser System (PLC Medical Systems, Milford, MA) were fired and a 5-mL cell suspension containing 21.5 x 10(6) bone marrow cells/mL was delivered by multiple injections into the myocardium. At 6 months after the procedure, another cardiac magnetic resonance imaging showed an almost complete resolution of the perfusion defect and an improvement in left ventricular contractility. |
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