| ABO血型不合的异基因造血干细胞移植治疗恶性血液病 |
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| 引用本文： | 邵晓雁,欧阳建,孙雪梅,许景艳,陈兵,杨永公.ABO血型不合的异基因造血干细胞移植治疗恶性血液病[J].实用临床医药杂志,2006,10(7):46-48. |
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| 作者姓名： | 邵晓雁 欧阳建 孙雪梅 许景艳 陈兵 杨永公 |
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| 作者单位： | 南京大学医学院附属鼓楼医院,血液科,江苏,南京,210008 |
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| 摘 要： | 目的探讨ABO血型不合异基因造血干细胞移植的疗效及并发症。方法回顾性分析14例ABO血型不合异基因造血干细胞移植患者的红系恢复情况,以评价血型不合、HLA是否相合等对红系恢复、造血重建、并发症等的影响。结果14例ABO血型不合患者仅1例发生纯红再障。13例ABO血型不合的患者(1例发生纯红再障未计算在内)与同期进行11例ABO血型相同的异基因造血干细胞移植患者比较,血红蛋白恢复在血型不合组明显延迟,中性粒细胞和血小板恢复两组无差异。此外,在血红蛋白恢复和血型转换的时间上血型不合的半相合造血干细胞组明显要迟于全相合,但其差异无统计学意义。结论ABO血型不合不影响造血干细胞移植的植活、相关合并症及预后。
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| 关 键 词： | 白血病 造血干细胞移植 血型不合 |
| 文章编号： | 1672-2353(2006)04-0046-03 |
| 修稿时间： | 2006年3月26日 |
ABO-INCOMPATIBLE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION TREATMENT MALIGNANT HEMATOLOGIC DISEASES |
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| SHAO Xiao-yan,OU YANG-Jian,SUN Xue-mei,XU Jin-yan,Chen Bin,Yang Yong-gong.ABO-INCOMPATIBLE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION TREATMENT MALIGNANT HEMATOLOGIC DISEASES[J].Journal of Clinical Medicine in Practice,2006,10(7):46-48. |
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| Authors: | SHAO Xiao-yan OU YANG-Jian SUN Xue-mei XU Jin-yan Chen Bin Yang Yong-gong |
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| Abstract: | Objective To explore the effect of ABO mismatch on clinical characteristics in allogeneic-hematopoietic stem cell transplantation(HSCT).Methods We retrospectively reviewed the clinical courses of 14 recipients of allo-HSCT from ABO-incompatible donors.Results One out of 14 recipients developed pure red cell aplasia(PRCA).The time of erythrocyterecovery after ABO-incompatible stem cell transplantation was delayed compared with ABO compatible stem cell transplantation.In addition,the time of erythrocyterecovery and the blood type switched after ABO-incompatible HLA-mismatched stem cell transplantation was delayed compared with HLA-matched allogeneic hematopoietic stem cell transplantation,but was not significantly different.Conclusion ABO-incompatibility has no adverse effect on the outcome of HSCT. |
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| Keywords: | Hematopoietic stem cell transplantation ABO incompatibility |
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