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Radical prostatectomy for high-risk prostate cancer: Biochemical outcome |
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| Authors: | Naoki Kawamorita Seiichi Saito Shigeto Ishidoya Akihiro Ito Hideo Saito Masanori Kato Yoichi Arai |
| Affiliation: | Departments of Urology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan, and;Department of Urology, Department of Organ-Oriented Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan |
| Abstract: | Objectives: To determine the biochemical outcome following radical prostatectomy alone in patients with high-risk prostate cancer. Methods: Between January 2002 and August 2007, 252 patients underwent radical retropubic prostatectomy. Those who received neoadjuvant hormone therapy were excluded from this analysis. Based on pre-operative data, we stratified the patients into low, intermediate, and high-risk groups according to the risk criteria of the National Comprehensive Cancer Network in 2003, respectively. Prostate-specific antigen (PSA) failure was defined as any detectable PSA level higher than 0.2 ng/mL. Results: The PSA failure-free survival rate for the high-risk group ( n = 46) was 64.5% after a median follow-up period of 39 months. Among patients with high-risk disease, none with pathologically organ-confined cancer ( n = 19) and a negative surgical margin had PSA failure. The PSA failure-free rate in patients with non organ-confined cancer ( n = 27) was 39.5%. Among the pretreatment variables, a positive biopsy core percentage (the number of positive biopsy cores/total biopsy core) ≥30 was a significant independent predictor of extra prostatic extension. Conclusions: Radical prostatectomy is feasible in high-risk prostate cancer patients, only if they have a pathologically organ-confined disease. |
| Keywords: | high grade high risk prostate cancer radical prostatectomy |