小儿高脂血症危险因素的临床抽样调查

目的通过临床抽样调查，探讨与小儿高脂血症发病有关的危险因素，为小儿高脂血症的早期检测提供客观指标。 方法北京大学第一医院儿科等于2004年9月，调查并分析了962名北京市景山学校在校学生(5~19岁)的血脂浓度，其中采用酶法测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL C)及低密度脂蛋白(LDL C)等4项指标。采用坐高、腰围、上臂围、体重指数来反映身体肥胖程度，进一步分析了这些指标与血脂浓度的关系。 结果在962名学生中，共检出高脂血症患儿122例，总检出率为12.7%。高脂血症组的坐高、腰围、上臂围、体重指数4项指标明显高于正常组，2组间差异有显著性(P<0.05)；坐高、腰围、上臂围、体重指数等4项指标与甘油三酯均呈高度显著正相关(P<0.01)，与高密度脂蛋白均呈高度显著负相关(P<0.01)。 结论正常组与高脂血症组的坐高、腰围、上臂围、体重指数4项指标差异均有显著性；坐高、腰围、上臂围、体重指数均是影响甘油三酯和高密度脂蛋白浓度的危险因素。

A clinical sampling study on risk factors in hyperlipidemia of children.

AbstractObjectiveTo discuss the risk factors of hyperlipidemia in children by sampling studies,and provide objective standard for the early monitoring of children hyperlipidemia. MethodsIn Sep.2004,962 students from Beijing Jingshan School between 5 and 19 years of age were investigated by the Department of Pediatrics of the First Hospital of Peking University,and enzymology was used to measure serum TC,TG,HDL C and LDL C.We used sitting height,waistline,arm girth and BMI to reflect the obesity,and analysed the relation between these indexes and blood lipids levels. ResultsOf 962 students,122 were found to have hyperlipidemia,and the proportion was 12.68%.The sitting height,waistline,arm girth and BMI of children with hyperlipidemia were evidently different from those of the normal subjects(P<0.05).A positive correlation was highly remarkable between these indexes and serum TG(P<0.01)and a negative correlation was highly remarkable between these indexes and serum HDL C(P<0.01). ConclusionResults suggest that sitting height,waistline,arm girth and BMI are the risk factors of hyperlipidemia in children.