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| 单肺通气期间麻醉期用药对肺内分流的影响 | |
| 引用本文： | 纪凡层,牟爱珍. 单肺通气期间麻醉期用药对肺内分流的影响[J]. 国际麻醉学与复苏杂志, 2016, 0(2). DOI: 10.3760/cma.j.issn.1673-4378.2016.02.014 |
| 作者姓名： | 纪凡层 牟爱珍 |
| 作者单位： | 潍坊市人民医院麻醉科,261041 |
| 摘 要： | 背景 低氧血症是单肺通气(one lung ventilation,OLV)期间最常见的并发症.缺氧性肺血管收缩(hypoxic pulmonary vasoconstriction,HPV)是肺血管对局部低氧分压的反射性收缩,可以减少肺内分流(pulmonary shunt fraction,Qs/Qt)、维持动脉血氧分压(partial pressure of arterial oxygen,PaO2)、防止低氧血症的发生.目的 探讨OLV期间麻醉期用药对Qs/Qt的影响,指导临床应用.内容 综述OLV期间麻醉期用药对机体HPV、Qs/Qt和PaO2的影响.趋向 OLV期间麻醉期用药可以对HPV产生抑制或增强作用,从而影响Qs/Qt和PaO2.临床上要避免使用抑制HPV作用、增加Qs/Qt的药物,防止患者出现低氧血症. |
| 关 键 词： | 单肺通气 药物 缺氧性肺血管收缩 肺内分流 |
Effects of drugs during anesthesia with one lung ventilation on pulmonary shunt fraction |
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| Abstract: | Background Hypoxemia is one of the most common complications during one lung ventilation(OLV).Hypoxemia pulmonary vasoconstriction (HPV) is a reflex contraction of vascular smooth muscle in the pulmonary circulation in response to low regional partial pressure of oxygen.It can decrease pulmonary shunt fraction (Qs/Qt) and improve oxygenation.Objective To discuss the effects of drugs during anesthesia with OLV on Qs/Qt.Content Many drugs during anesthesia have an effect on HPV, Qs/Qt and oxygenation.Trend Drugs during anesthesia with OLV can inhibit or enhance the response of HPV, increase or decrease the Qs/Qt.We should avoid of drugs that inhibit the response of HPV and increase Qs/Qt.It can help patients to avoid of hypoxia. |
| Keywords: | One lung ventilation Drugs Hypoxic pulmonary vasoconstriction Pulmonary shunt fraction |
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