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| 黑素瘤与DNA甲基化研究进展 | |
| 引用本文： | 陈翠,蔡丽敏,王永晨. 黑素瘤与DNA甲基化研究进展[J]. 国际皮肤性病学杂志, 2016, 0(2): 125-128. DOI: 10.3760/cma.j.issn.1673-4173.2016.02.019 |
| 作者姓名： | 陈翠 蔡丽敏 王永晨 |
| 作者单位： | 150001,哈尔滨医科大学附属第一医院皮肤科 |
| 基金项目： | 黑龙江省博士后科研启动金(LBH-Q14109)，Postdoctoral Scientific Research Foundation of Heilongjiang Province of China(LBH-Q14109) |
| 摘 要： | 黑素瘤作为一种侵袭性强的皮肤恶性肿瘤,在发病率和死亡率方面都在上升,目前仍缺乏较为有效的治疗手段.近年来,随着人们对黑素瘤认识的逐渐深入,黑素瘤的表观遗传学修饰特别是在DNA甲基化方面的研究也受到广泛关注.DNA甲基化在肿瘤细胞中的改变相对较常见,包括黑素瘤细胞.因此,DNA甲基化相关基因可以作为黑素瘤早期筛查、诊断、预后、治疗分期以及治疗后监测的生物标记. |
| 关 键 词： | 黑色素瘤 DNA甲基化 后成说,遗传 分子靶向治疗 基因 |
DNA methylation in melanoma |
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| Abstract: | Melanoma is a highly aggressive malignant cutaneous tumor that has been increasing in incidence and mortality.Effective therapeutic approaches are unavailable currently.With further insights into melanoma,epigenetic modification,especially DNA methylation,in melanoma has drawn extensive attention in recent years.Changes in DNA methylation are relatively common in tumor cells,including melanoma cells.Thus,DNA methylation-related genes may serve as biomarkers for early screening for,as well as diagnosis,prediction of prognosis,staging,treatment,and post-therapeutic surveillance of melanoma. |
| Keywords: | Melanoma DNA methylation Epigenesis,genetic Molecular targeted therapy Genes |
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