105例晚期非小细胞肺癌预后因素分析

目的]探讨晚期非小细胞肺癌（NSCLC）患者的预后相关因素。方法]回顾性分析2003年1月1日至2009年12月31日105例晚期非小细胞肺癌死亡患者的临床资料,对可能影响其预后的相关因素进行单因素和多因素分析。结果]全组患者1、2、3年生存率分别为27.6%、8.6%、1.9%,中位生存时间为9.0个月（95%CI：7.9～10.1个月）。单因素分析显示临床分期、PS评分、首诊伴脑转移、肝转移、骨转移以及治疗方式与预后相关。多因素分析显示临床分期、PS评分、首诊伴脑转移、治疗方式是影响晚期非小细胞肺癌预后的独立因素。结论]临床分期、PS评分、首诊伴脑转移、治疗方式可能是晚期非小细胞肺癌患者的独立预后因素。

An Analysis of Prognostic Factors in 105 Cases with Advanced Non-small Cell Lung Cancer

Purpose] To investigate the prognostic factors of advanced non-small cell lung cancer （NSCLC）.Methods] The clinical data of 105 cases with advanced non-small cell lung cancer from Jan. 1, 2003 to Dec. 31, 2009 were analyzed retrospectively. The potential prognostic factors were evaluated by univariate and multivariate analyses. Results] The 1-, 2- and 3-year survival rate was 27.6%, 8.6% and 1.9%, respectively, median survival time was 9.0 months （95%CI：7.9～10.1 months）. Univariate analysis showed that clinical stage, performance status（PS）, treatment modality and initial diagnosis with brain metastasis or liver metastasis or bone metastasis were significantly related to the survival. And multivariate analysis showed that clinical stage, PS, treatment modality and brain metastasis at initial diagnosis were independent prognostic factors. Conclusion] Clinical stage, PS, brain metastasis at initial diagnosis and treatment modality may be independent prognostic factors of advanced non-small cell lung cancer.