Passive mechanical properties of cardiac tissues in heart hypertrophy during pregnancy |
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| Authors: | Adolfo?Virgen-Ortiz J.?L.?Marin A.?Elizalde E.?Castro E.?Stefani L.?Toro J.?Mu?iz |
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| Affiliation: | 1.Departamento de Ciencias Químico-Biológicas, Unidad Regional Sur Campus Navojoa,Universidad de Sonora,Navojoa,Mexico;2.Departamento de Investigación en Física, Campus Hermosillo,Universidad de Sonora,Hermosillo,Mexico;3.Unidad de Investigación Enrico Stefani Bonfanti, Centro Universitario de Investigaciones Biomédicas,Universidad de Colima,Colima,Mexico;4.Unidad de Investigación Carlos Méndez, Centro Universitario de Investigaciones Biomédicas,Universidad de Colima,Colima,Mexico;5.Department of Anesthesiology,David Geffen School of Medicine at the University of California,Los Angeles,USA;6.Department of Physiology,David Geffen School of Medicine at the University of California,Los Angeles,USA;7.Department of Molecular and Medical Pharmacology,David Geffen School of Medicine at the University of California,Los Angeles,USA |
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| Abstract: | ![]()
We evaluated changes in passive mechanical properties in cardiac tissues during rat pregnancy. Left and right ventricular free walls were dissected from hearts of nonpregnant, late-pregnant, and postpartum rats. Mechanical experiments in ventricular strips were done by stretch–release cycles using a step motor. The results show that during pregnancy, there is cardiac hypertrophy associated with (1) an increase in myocyte size, particularly of augmented myocyte length, (2) a decrease in passive tension developed by the myocardial walls, and (3) a decrease in both elastic modulus and hysteresis. All changes observed during rat pregnancy were reversed during postpartum. In conclusion, a heart with less ventricular rigidity could contribute to facilitating the ventricular filling in conditions of a greater circulating volume characteristic of pregnancy. J. L. Marin deceased: 16 November 2007. |
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| Keywords: | Cardiac hypertrophy Pregnancy Passive tension |
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