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人脐带间充质干细胞在帕金森病的应用进展
引用本文:邵丽诗,马逸群,梁磊,罗成诚,王家平. 人脐带间充质干细胞在帕金森病的应用进展[J]. 当代医学, 2021, 0(13): 191-194
作者姓名:邵丽诗  马逸群  梁磊  罗成诚  王家平
作者单位:昆明医科大学第二附属医院放射科;昆明医科大学第一附属医院肿瘤外科;临沧市云县人民医院急诊科
基金项目:国家自然科学基金(地区科学基金项目)(8186030172)。
摘    要:帕金森病(Parkinson's disease,PD)是一种复杂的神经系统疾病,其典型病理特征为与黑质多巴胺能(DA)神经元丢失有关的运动系统功能受损.目前尚无有效的治疗方法逆转DA神经元的进行性损失阻止PD的恶化.近年来,干细胞移植意逐渐被临床用于治疗神经退行性疾病,包括间充质干细胞(mesenchvmal ste...

关 键 词:帕金森病  治疗  人脐带间充质干细胞

Research advances in human umbilical cord mesenchymal stem cells for Parkinson's disease
SHAO Lishi,MAYiqun,LIANG Lei,LUO Chengcheng,WANG Jiaping. Research advances in human umbilical cord mesenchymal stem cells for Parkinson's disease[J]. Contemporary Medicine, 2021, 0(13): 191-194
Authors:SHAO Lishi  MAYiqun  LIANG Lei  LUO Chengcheng  WANG Jiaping
Affiliation:(Department of Radiology,The Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,650101;Department of Surgical Oncology,The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,650000;Department of Emergency Surgery,The People's Hospital of Yunxian,Lincang,Yunnan,675800)
Abstract:Parkinson's disease(PD)is a complex nervous system disease.Its typical pathological feature is the impairment of motor system function related to the loss of dopaminergic(DA)neurons in substantia nigra.At present,there is no effective treatment to reverse the progressive loss of DAneurons and prevent the deterioration of PD.In recent years,stem cell transplantation has gradually been used in the treatment of neurodegenerative diseases,including mesenchymal stem cell(MSCs)transplantation.Human umbilical cord mesenchymal stem cells(hUC-MSCs)have more obvious advantages than other sources of MSCs,and have been widely used in the treatment of variety of diseases.MSCs can differentiate into DAneurons and secrete variety of protective factors.This paper reviewed the characteristics of hUC-MSCs and its application in the treatment of PD,and analyzes the existing problems of hUC-MSCs in the treatment of PD,so as to provide new ideas for stem cell regenerative medicine in the treatment of PD.
Keywords:Parkinson's disease  Treatment  Human mesenchymal umbilical cord stem cells
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