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Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N-[11C]Methyl-AMD3465 PET |
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| Authors: | Hartimath SV Draghiciu O. Daemen T Nijman H.W. van Waarde A. Dierckx R.A.J.O. de Vries E.F.J. |
| Affiliation: | 1.Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 31.001, 9713, GZ, Groningen, The Netherlands ;2.Department of Medical Microbiology, Tumor Virology and Cancer Immunotherapy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands ;3.Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands ; |
| Abstract: | Molecular Imaging and Biology - Chemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor... |
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