| 胶原酶对裸鼠移植肥厚性瘢痕的治疗作用 |
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| 引用本文： | 武继祥,陈德英,吴宗耀. 胶原酶对裸鼠移植肥厚性瘢痕的治疗作用[J]. 中华烧伤杂志, 1999, 0(3) |
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| 作者姓名： | 武继祥 陈德英 吴宗耀 |
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| 作者单位： | 第三军医大学西南医院康复理疗科，第三军医大学组织胚胎教研室，第三军医大学西南医院康复理疗科 400038重庆，400038重庆 |
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| 摘 要： | 目的观察胶原酶对肥厚性瘢痕(HTS)胶原降解的影响,探讨它对 HTS 的治疗作用。方法建立 HTS 裸鼠移植模型,局部注射胶原酶于瘢痕组织。治疗后取材行光、电镜观察和分析。结果 HTS 组织胶原纤维被降解,真皮层变薄,瘢痕缩小,质地变软,与对照组差异十分明显。结论胶原酶的局部注射可能是治疗 HTS 的较好方法。
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| 关 键 词： | 肥厚性瘢痕 裸鼠 胶原酶 胶原降解 |
The effect of intradermal injection of collagenase in implanted hypertrophic scar in nude mice |
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| WU Jixiang CHEN Deying WU Zongyao. The effect of intradermal injection of collagenase in implanted hypertrophic scar in nude mice[J]. Chinese journal of burns, 1999, 0(3) |
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| Authors: | WU Jixiang CHEN Deying WU Zongyao |
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| Affiliation: | WU Jixiang CHEN Deying WU Zongyao Department of Physical Medicine and Rehabilitation,Southwest Hospital,Third Military Medical University,Chongqing 400038 |
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| Abstract: | Objective Effects of collagen degradation in hypertrophic scar by intradermal injection of collagenase were observed.Methods Hypertrophic scar was implanted into nude mice and collagenase was injected locally.Light and electron microscopic observations were carried out.Results Collagen degradation in hypertrophic scar by intradermal injecton of collagenase was observed.The implanted scars became soft,thin and small.Conclusion These results suggested that local injection of collagenase may be a useful therapeutic tool for hypertrophic scar. |
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| Keywords: | Hypertrophic scar Nude mice Collagenase Collagen degradation |
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