多发性骨髓瘤骨髓象分析及Hb、hsCRP和IL-6检测的临床意义

目的探讨血红蛋白（Hb）、血清超敏C反应蛋白（hsCRP）、白细胞介素6（IL-6）检测在多发性骨髓瘤诊断中的应用价值以及骨髓细胞形态学在MM诊断中的作用。方法对30例入院初诊为多发性骨髓瘤患者和50例健康体检者（对照组）进行血细胞分析，采用免疫散射比浊法检测血清超敏C反应蛋白（hsCRP）、采用酶免法检测白细胞介素6（IL-6），并对30例MM患者进行骨髓细胞形态分析。结果30例MM患者Hb明显低于健康对照者（P〈0．05），hsCRP及IL-6明显高于健康对照者（P〈0．05），30例MM患者中骨髓瘤细胞比例在15％-80％28例，2例低于10％。结论血红蛋白（Hb）及血清超敏C反应蛋白（hscRP）、白细胞介素6（IL-6）检测对MM的诊断有重要意义，骨髓检查对MM具有特异的诊断价值。

Analysis of marrow cell morphology and clinical significance of Hb and hs-CRP,IL-6 in multiple myeloma

Objective To investigate the clinical significance of Hb and hs - CRP, IL - 6 and the effect of bone marrow cell morphology in multiple myeloma. Methods The study was performed in 30 MM pafients（MM group） and 50 healthy controls（control group）, all the subjects were taken to analysis Hb, hs - CRP by immunity transmission turbidity method, IL - 6 by enzyme - linked immunosorbent assay method, myeloma cell ratio and morphology type were analysed in bone marrow. Results There were sigxfificant difference of the level Hb, hs - CRP and IL-6（（P 〈 0.05）between MM and healthy control group. The proportion of neoplastic cell inceased significantly. Conclusion Measurement of Hb and hs - CRP, IL - 6 in multiple myeloma may have an important clinical significance to diagnose multiple myeloma. Analysis of marrow cell morphology is an peculiar method in MM diagnosis.