| 川芎嗪对大鼠加速型抗GBM抗体肾炎肾皮质的线粒体膜流动性和ATP酶活性的影响 |
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| 引用本文： | 傅红,黎七雄. 川芎嗪对大鼠加速型抗GBM抗体肾炎肾皮质的线粒体膜流动性和ATP酶活性的影响[J]. 华西药学杂志, 2004, 19(1): 13-15 |
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| 作者姓名： | 傅红 黎七雄 |
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| 作者单位： | 武汉大学医学院药理学系,湖北,武汉,430071;武汉大学医学院药理学系,湖北,武汉,430071 |
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| 基金项目： | 湖北省卫生厅基金资助项目 (WJ0 15 5 5 ) |
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| 摘 要： | 目的 观察川芎嗪对大鼠加速型抗肾小球基底膜(GBM)抗体肾炎肾皮质线粒体膜流动性和ATP酶活性的影响。方法采用1，6-二苯基-1，3，5-己三烯(DPH)荧光偏振法研究抗GBM肾炎肾皮质的线粒体膜流动性，利用定磷法测定线粒体膜ATP酶的活性。结果川芎嗪能调节抗GBM抗体肾炎肾皮质的线粒体膜流动性，同时可以使Na^ -K^ -ATPase、Mg^ -ATPase、Ca^2 -ATPase活力升高。结论川芎嗪可能通过改善肾线粒体膜流动性，而保护线粒体膜结构及功能。
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| 关 键 词： | 川芎嗪 抗肾小球基底膜抗体肾炎 线粒体膜流动性 ATP酶 |
| 文章编号： | 1006-0103(2004)01-0013-03 |
| 修稿时间： | 2003-10-01 |
Effects of tetramethylpyrazine on membrane fluidity and ATPase activity of renal cortex mitochondria in accelerated anti-GBM antibody nephritis of rats |
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| FU Hong,LI Qi-xiong. Effects of tetramethylpyrazine on membrane fluidity and ATPase activity of renal cortex mitochondria in accelerated anti-GBM antibody nephritis of rats[J]. West China Journal of Pharmaceutical Sciences, 2004, 19(1): 13-15 |
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| Authors: | FU Hong LI Qi-xiong |
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| Abstract: | OBJECTIVE To investigate the effects of tetramethylpyrazine(TMP) on membrane fluidity and ATPase activity of renal cortex mitochondria in accelerated anti-glomerulus basement membrane(GBM) antibody nephritis of rats.METHODS The changes in membrane fluidity of renal cortex mitochondria in accelerated anti-GBM antibody nephritis of rats were measured by 1,6-diphenyl-1,3,5-hexatriene(DPH).The activity of ATPase was detected by determining phosphorum.RESULTS TMP could increase membrane fluidity and the activity of Na +-K +-ATPase,Mg 2+-ATPase and Ca 2+-ATPase.CONCLUSION TMP can protect mitochondria structure and function through improving membrane fluidity. |
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| Keywords: | Tetramethylpyrazine Anti-GBM antibody nephritis Mitochondria Membrane fluidity ATPase |
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