拉米夫定初始联合阿德福韦醅及中药治疗慢性乙型肝炎30例效果观察

目的：观察拉米夫定初始联合阿德福韦酯及中药治疗慢性乙型肝炎的临床疗效。方法：将60例慢性乙型肝炎患者随机分为观察组、对照组各30例。2组均给予拉米夫定100mg／次，1次／d初始治疗，第2个月时加用阿德福韦酯10mg／次，1次／d，口服。2组均行维生素B、维生素C等常规护肝治疗。观察组同时给予中药水煎分服，1剂／d。2组均以1个月为1个疗程，治疗2个疗程后观察疗效。结果：观察组显效43例，占95．6％；部分有效1例，占2．2％；无效1例，占2．2％；总有效率为97．8％。对照组显效28例，占62．2％：部分有效8例，占17．8％；无效9例，占20．0％；总有效率为80．0％。观察组总有效率明显优于对照组（P〈0．05）。ALT、AST、e抗原转阴率、e抗原血清转换率、耐药率、TBIL等指标2组治疗前后均明显好转（P〈0．05），观察组改善较对照组明显（P〈0．05）。结论：拉米夫定初始联合阿德福韦酯及中药治疗慢性乙型肝炎临床疗效显著。

Lamivudine Initially Combined with Adefovir Dipivoxil and Herbs in Treating 30 Cases of Chronic Hepatitis B

Objective： To observe clinical effects of lamivudine initially combined with adefovir dipivoxil and herbs in treating chronic hepatitis B （CHB）. Method： All 60 patients were randomly assigned into observation group and control group. Both groups were administered with lamivudine, 100mg each time, once each day, adefovir dipivoxil at the second month, 10mg each time, once each day, taking orally; conventional protection liver therapy. Observation group were also given with herbs, one dose each day. One month was one session, to observe clinical effects after two sessions. Result： A total of 43 cases were effective remarkably in observation group and accounted for 95.6%; one case effective and 2.2%; one case ineffective and 2.2%; total effective rate was 97.8%. 28 cases in control group were effective notably and reached 62.2%; eight cases effective and 17.8%; nine cases ineffective and 20.0%; total effective rate was 80.0%. Observation group was superior to control group obviously （P〈0.05）. Indexes of both groups improved significantly after treating than before treating which were ALT, AST, negative rate of e-antigen, drug resistance rate, TBIL and others （P〈0.05）, observation group improved more evidently than control group （P〈0.05）. Conclusion： Lamivudine combined with adefovir dipivoxil initially and herbs can gain remarkable effects in treating CHB.