度洛西汀与氟西汀治疗抑郁症的对照研究

目的：比较度洛西汀与氟西汀治疗抑郁症的疗效及安全性。方法：将60例抑郁症患者随机分为两组,分别用度洛西汀和氟西汀治疗,疗程6周。采用汉密尔顿抑郁量表（HAMD）评定临床疗效,副反应量表（TESS）评定不良反应。结果：度洛西汀组显效率为66.7%,有效率为86.7%;氟西汀组分别为63.3%和83.3%。两组差异无统计学意义（P〉0.05）。治疗第1周末时,度洛西汀组HAMD评分显著低于氟西汀组（P〈0.05）。两组不良反应轻微。结论：度洛西汀和氟西汀抗抑郁疗效肯定,不良反应轻。

Comparative study for duloxetine and fluoxetine in treatment of depression

Objective： To compare efficacy and safety of duloxetine and fluoxetine in treatment of depression.Methods： Sixty patients with depression were randomly assigned to duloxetine group and fluoxetine group,and treated for 6weeks.The clinical efficiency was evaluated by Hamilton depression scale（HAMD）,and adverse reactions were assessed with Treatment emergent symptom scale（TESS）.Results： The obvious effective rates and the effective rates in duloxetine group and fluoxetine group were 66.7% and 86.7%,63.3% and 83.3% respectively;and no significant difference was found between the two groups（P 0.05）.However,the total score of HAMD in duloxetine group was significantly lower than that in fluoxetine group one week after the treatment.The adverse reactions of the two groups were fewer and milder.Conclusions： Both duloxetine and fluoxetine are effective antidepressants with fewer side effects.