米氮平与氟西汀对抑郁症患者生活质量的对照研究

目的：探讨米氮平和氟西汀对抑郁症患者的生活质量的影响。方法：将76例符合CCMD-3抑郁症诊断标准的患者随机分为两组,分别给予米氮平和氟西汀进行治疗。给予汉密尔顿抑郁量表（HAMD）评定患者的临床疗效,用药物副反应量表（TESS）评定不良反应严重程度,用生活质量综合评定问卷（GQOLI-74）评价患者的生活质量。结果：治疗8周末时,米氮平组有效率80%,氟西汀组有效率75%,两组总有效率比较差异无统计学意义（x2=0.689,P〉0.05）;两组HAMD评分均较治疗前有显著性下降（t=4.642,3.251,P〈0.01）,但米氮平组在治疗2周末,即有明显下降（t=2.156,P〈0.05）,两组治疗2周末相互比较存在明显差异性（t=3.398,P〈0.05）。治疗8周末,米氮平组除物质生活外,其余三项评分均较治疗前有显著性改善（t=2.431~3.684,P〈0.05或P〈0.01）,而氟西汀组除心理功能较前有改善外（t=3.572,P〈0.05）,其余三项均无显著性改善（P〉0.05）。两组间相比较,治疗末米氮平组除物质生活外,其余三项评分均较氟西汀组有明显改善,具有统计学意义（P〈0.05或P〈0.01）。结论：与氟西汀组相比,米氮平更能改善抑郁症患者的生活质量。

Control study for effects of mirtazapine and fluoxetine on life quality of patients with depression

Objective： To explore effects of mirtazapine and fluoxetine on life quality of patients with depression.Methods： 76 cases meeting CCMD-3 criteria for depression were randomly divided into mirtazapine group and fluoxetine group,wherein these cases were treated with mirtazapine and fluoxetine,respectively.Before and after the treatment,the clinical effects were evaluated by Hamilton depression scale（HAMD）,the side effects were evaluated by treatment emergent symptom scale（TESS）,and the life quality was evaluated by generic quality of life inventory-74（GQOLI-74）.Results： 8 weeks after the treatment,the effective rates of mirtazapine group and fluoxetine group were 80% and 75%,respectively,and the difference was statistically insignificant（x2= 0.689,P 0.05）.The HAMD scores of the two groups decreased significantly compared with those before the treatment（t = 4.642,3.251,both P 0.01）;however,the significant decrease occurred in mirtazapine group 2 weeks after the treatment（t = 2.156,P 0.05） and there was a significant difference between the two groups（t = 3.398,P 0.05）.8 weeks after the treatment,the mirtazapine group was obviously improved in other three life quality factors except the material life factor（t = 2.431-3.684,P 0.05 or P 0.01）,while fluoxetine group had no significant improvement in the life quality（t = 3.572,P 0.05） except psychological functions（t = 3.572,P 0.05）.After the treatment,except the material life factor score,other three factor scores of mirtazapine group were all higher than those of fluoxetine group,and the differences had the statistical significance（P 0.05 or P 0.01）.Conclusions： Mirtazapine is more useful for improving the life quality of the depressive patients,compared with fluoxetine.