热休克蛋白与白内障发生的研究进展

热休克蛋白(heat shock proteins,HSPs)最初发现是细胞在物理刺激下(如热刺激等)产生的一种应激蛋白,随着后来的大量研究发现,HSPs是一切生物体在许多应激状态下(如高温、重金属、缺氧、乙醇、病毒及细菌感染等)合成增加的一种在进化上高度保守的细胞应激蛋白。作为分子伴侣,Hsps在蛋白质的折叠,稳定性,合成等方面发挥重要作用。晶状体浑浊称为白内障,是最常见的致盲原因之一,大量的研究表明,白内障的发生与自由基的产生,氧化损伤,晶体蛋白比例改变及晶状体上皮细胞的凋亡有直接关系.近年来的研究表明,晶状体能表达一系列的HSP,它们对维持晶状体的稳定和透明起到关键作用。本文就热休克蛋白与白内障近年的研究情况做一综述。

Recent advances in research of heat shock proteins and cataract

The hot shock proteins(heat shock proteins,HSPs)were first discovered as the stress protein which produces under physical stimulation(e.g.hot stimulation,etc.).With the discoveries of massive researches afterwards,HSPs were found to be the highly evolution-conservative cell stress proteins that were synthesized by all organisms under several stress conditions(e.g.high temperature,heavy metal,hypoxia,ethyl alcohol,uiral or bacterial infection,etc.).As molecular companion,HSPs plays a vital role in protein folding,stability and synthesis.Crystalline lens opacification,also called cataract,is one of the most common causes of blindness.Several researches indicated that the development of cataract was related to production of free radical,oxidation damage,changes of the crystal protein proportion and the lens epithelial cells apoptosis.Recent researches indicated that crystalline lens can express a series of HSPs and plays important roles in maintaining the stability and transparency of crystalline lens.This article reviewed the recent advances in the researches on heat shock proteins and cataract.