The gene for staphylococcal protein A |
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| Affiliation: | 1. Department of Biochemistry and Biotechnology. Royal Institute of Technology, S-100 44 Stockholm, Sweden;2. Department of Microbiology, University of Uppsala, Biomedical Center, Box 581, S-751 23 Uppsala, Sweden;3. European Molecular Biology Laboratory (EMBL), Postfach 1022.09, D-6900 Heidelberg 1, FRG;1. International Education and Research Center for Food and Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan;2. International Research and Development Center for Mucosal Vaccine, Institute of Medical Science, University of Tokyo, Tokyo, Japan;3. Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, Mie, Japan;4. Mucosal Vaccine and Adjuvant Project, Research Institute for Microbial Diseases, Osaka University, Suita, Japan;1. Healthcare Innovation Centre, Teesside University, Middlesbrough, Tees Valley TS1 3BX, UK;2. Equipe de Chimie Bioorganique et BioInorganique (ECBB), Institut de Chimie Moléculaires et des Matériaux d′Orsay (ICMMO), UMR-CNRS 8182, Univ Paris Sud, Université Paris-Saclay, 91405 Orsay, France;3. Department of Electronics Technology, Budapest University of Technology and Economics, Budapest, Hungary;4. Fraunhofer EMFT, Institution for Microsystems and Solid State Technologies, Munich, Germany;5. IBEC-Institute for Bioengineering of Catalonia, Barcelona Institute of Science and Technology (BIST), Barcelona, Spain;1. International Joint Research Laboratory for Lipid Nutrition and Safety, Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China;2. Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;3. Interdisciplinary Nanoscience Centre, Aarhus University, 8000 Aarhus, Denmark;1. Energy Biosciences Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA;2. School of Food Science and Biotechnology, Kyungpook National University, Daegu, Korea;3. Energy Biosciences Institute, University of California, Berkeley, CA, USA;4. Department of Bioengineering, University of California, Berkeley, CA, USA;5. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA;6. Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame,, South Bend, IN, USA;7. Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA;8. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA;9. Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA;1. Division of Nephrology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH;2. Division of Pediatric Cardiology, Lucile Packard Children’s Hospital, Stanford University, Palo Alto, CA |
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| Abstract: | ![]()
Protein A from Staphylococcus aureus has become an important tool in immunology and molecular biology due to its specific binding to the constant region of immunoglobulins (Igs) from most mammalian species1. Many qualitative and quantitative techniques have been developed which take advantage of this ‘pseudo-immune’ reaction2. In addition, solid state protein A has recently been introduced in medical therapy to decrease the amount of circulating immune complexes in sera3. In this article Mathias Uhlén, Martin Lindberg and Lennart Philipson describe the structure of the protein A molecule and its gene. They also discuss the possibilities for fusing the protein A gene to other genes. |
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