Distribution and stability of [111In]bleomycin and its fractions in tumor-bearing mice |
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| Affiliation: | 1. Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation, School of Life Sciences, Southwest University, Chongqing 400715, China;2. Chongqing Productivity Promotion Center of Chinese Traditional Medicine Mod-ernization, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China |
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| Abstract: | ![]()
The tissue distributions in glioma-bearing mice given injections of [111In]bleomycin (BLM) indicated that tumor concentrations and ratios of tumor to blood, muscle and brain for [111In]BLM-B2 and -A2 were higher than those for unfractionated [111In]BLM. Autoradiographs of electrophoretic gels of urine containing [111In]BLM or one of its fractions differed from those containing 111InCl3 [111In]BLM and its fractions (A2 and B2) were found to be stable in vivo. The fractions may be more useful in the clinic than [111In]BLM. |
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