The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Ia-reactive T cells |
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| Affiliation: | 1. Livzon Mabpharm Inc, Zhuhai, China;2. State Key Laboratory of Natural Medicines, Department of Chinese Medicines Analysis, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China;3. AbCyte Therapeutics, Inc, San Jose, California, USA;1. Department of Rehabilitation, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. Department of Rehabilitation, Xinhua Hospital (Chongming Branch), Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China;3. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China;4. Department of Rehabilitation, Liuzhou Maternal and Child Healthcare Hospital, Liuzhou, Guangxi 545001, China |
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| Abstract: | ![]()
Murine models of systemic lupus eRythematosus (SLE) have significantly contributed to our understanding of human autoimmunity. One such strain, the MRL-lpr/lpr, spontaneously develops an autoimmune disease manifested clinically by arthritis, vasculitis, immune-complex glomerulonephritis and autoantibody production1–3. In this article Yvonne Rosenberg and her colleagues suggest a theoretical basis for the development of autoimmunity in MRL-lpr/lpr mice. |
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