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| MAB225对人唾液腺腺样囊性癌细胞放射敏感性的影响 | |
| 引用本文： | 刘浏,刘秀明,吕燕,胡海生,蔡以理. MAB225对人唾液腺腺样囊性癌细胞放射敏感性的影响[J]. 上海口腔医学, 2011, 20(6): 603-607 |
| 作者姓名： | 刘浏 刘秀明 吕燕 胡海生 蔡以理 |
| 作者单位： | 上海交通大学医学院附属第九人民医院·口腔医学院 口腔颌面外科,上海市口腔医学重点实验室,上海200011 |
| 摘 要： | 目的:研究表皮生长因子受体单克隆抗体(MAB225)对人唾液腺腺样囊性癌(ACC)细胞放射敏感性的影响。方法:通过双荧光染色法、四氮唑还原法(MTT)、流式细胞仪观察经MAB225处理后的ACC-2细胞放射后凋亡的变化,以评价MAB225对ACC-2细胞放射敏感性的影响。采用SPSS11.0软件包的单因素方差分析对数据进行统计学处理。结果:经MTT检测、双荧光染色和流式细胞仪检测,经MAB225和放射联合处理后的ACC-2细胞,其细胞凋亡比例较未处理组上升3倍;而单纯放射处理的ACC-2细胞,其细胞凋亡比例只增加1倍。结论:MAB225可以提高放射线对ACC-2细胞的杀伤作用,降低ACC-2细胞的放射后生存率。 |
| 关 键 词： | 表皮生长因子受体 单克隆抗体 腺样囊性癌 放射 唾液腺 |
The effect of MAB225 on radiosensitivity of salivary gland adenoid cystic carcinoma |
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| LIU Liu , LIU Xiu-ming , LV Yan , HU Hai-sheng , CAI Yi-li. The effect of MAB225 on radiosensitivity of salivary gland adenoid cystic carcinoma[J]. Shanghai journal of stomatology, 2011, 20(6): 603-607 | |
| Authors: | LIU Liu LIU Xiu-ming LV Yan HU Hai-sheng CAI Yi-li |
| Affiliation: | LIU Liu,LIU Xiu-ming,LV Yan,HU Hai-sheng,CAI Yi-li.(Department of Oral and Maxillofacial Surgey,Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China) |
| Abstract: | PURPOSE:To observe the effect of epidermal growth factor receptor's monoclonal antibody(MAB225) on radiosensitivity of salivary gland adenoid cystic carcinoma cell.METHODS: Bi-fluorescence stain,MTT test and fluorescence flow cytometry(FCM) were used to observe the apoptosis rate and radiosensitizing effect for MAB225 on ACC-2 cell.SPSS11.0 software package was used for data analysis.RESULTS: Through bi-fluorescence stain,MTT test and fluorescence flow cytometry(FCM),it was found that MAB225 combined with r... |
| Keywords: | EGFR Monoconal antibody Adenoid cystic carcinoma Radiation Salivary gland |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |