异丙酚诱导插管对血浆降钙素基因相关肽及内皮素水平的影响

目的 探讨异丙酚诱导插管对血浆ＣＧＲＰ含量的影响。方法 择期手术病人３６例，ＡＳＡⅠ～Ⅱ级，随机分为异丙酚（ＰＰ组，２０例）硫喷妥钠（ＳＰ组，１６例）两组，分别于麻醉前、用药后、插管后２ｍｉｎ、７ｍｉｎ、１５ｍｉｎ测定血浆中ＣＧＲＰ、ＥＴ的含理及血液动力学变化。结果 两组给药后血压均下降，插管后硫喷妥钠组血压迅速上升，异丙酚组插管后ＣＧＲＰ、ＥＴ含量略有下降，但无统计学意义（Ｐ〉０．０５）。硫喷妥

Changes of plasma calcitonin gene-related peptide and endothelin concentrations during induction anesthesia and intubation following propofol administration

Objective To observe the changes of plasma calcitonin gene-related peptide (CGRP) and endothelin (ET) during propofol-induced anesthesia and intubationMethods Thirty-six patients were randomly allocated to receiving intravenous administration with propofol 2mg/kg ( group PP, n=20) or sodium thiopental group (SP, n=16) The venous bloos samples were taken to measure the plasma CGRP and endothelin (ET) concentrations, together with systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR), immediately before induction, 2min after P or SP administration, 2min, 7min, 15min after intubationResults SBP decreased immediately after induction in both groups (P<001), but increased after intubation in group SP The plasma levels of CGRP and ET remained unchaged significantly after intubation in group PP (P>005), increased markedly in group SP (P<001)Conclusions The inhibitory effect of propofol on cardiovascular response to endotrocheal intubation is not mediated via the increase of plasma CGRP