遗忘型轻度认知障碍杏仁核功能连接静息态纵向变化功能磁共振研究

目的：探讨静息状态下遗忘型轻度认知障碍（aMCI）杏仁核功能连接在随访（13．0±2．2）个月前后的纵向变化。方法：纳入经临床确诊的13例aMCI患者，于纳入研究时及随访时接受静息态功能 MRI扫描，使用SPM8软件分析，采用感兴趣区种子体素分析方法，比较杏仁核功能连接前后两次的差异，分析杏仁核功能连接强度变化与神经心理评估结果之间的关系。结果：与基线对比，aMCI 随访后蒙特利尔认知评估量表（MoCA）成绩下降，差异有统计学意义（P＜0．05）。同时与基线相比，aMCI随访后与左侧杏仁核功能连接明显降低的区域有双侧颞中回/枕中回、左侧额中回/前扣带回、左侧楔叶/后扣带回/楔前叶结合部，与右侧杏仁核功能连接明显降低的区域为左侧额中回/前扣带回，然而与右侧杏仁核功能连接明显增强的区域为左侧额上回/额中回。重要的是杏仁核与以上脑区间功能连接的改变与认知能力呈正相关。结论：在aMCI向阿尔茨海默病转化过程中，杏仁核与多个脑区之间出现功能连接异常，可能是评价aMCI 演变的一个潜在的生物学标志。

Study on longitudinal alteration of amygdala functional connectivity in the amnestic mild cognitive impairment by resting-state fMRI

Objective：To investigate the longitudinal alteration of the functional connectivity of the amygdala in the rest status of the amnestic mild cognitive impairment （aMCI）subjects during an average period of 13±2.2 months follow-up.Methods：Thirteen aMCI subjects were included and received rest-state functional magnetic resonance imaging examination both at the baseline and 13±2.2 months later.The difference of the functional connectivity of the amygdala between the baseline and follow-up was analyzed by the SPM8 software and the ROI seeding method.The relationship between the neuropsychological tests and the longitudinal alteration of the functional connectivity of the amygdala was studied.Results：Compared with the baseline,the MoCA scores were decreased in the follow-up aMCI subjects and the difference was statistically significant （P＆lt;0.05）.Meanwhile compared with the baseline aMCI subjects,for the left amygdala,a decreased functional connectivity was found in several regions,including the bilateral middle temporal/occipital gurus （MTG/MOG）,the left middle frontal gyrus/anterior cingulate cortex （MFG/ACC）,and the conjunctional region of the left cuneus/posterior cingulate cortex/precuneus （Cun/PCC/Pcu）.In the right amygdala of the follow-up aMCI subj ects and compared with base-line,decreased functional connectivity was found in the conjunctional region of the left middle frontal gyrus/anterior cingulate cortex （MFG/ACC）,while increased functional connectivity was found in the conj unctional region of the left superior frontal gyrus/middle frontal gyrus （SFG/MFG）.Importantly,the altered functional connectivity between the amygdala and the above mentioned regions was positively correlated with cognitive abilities.Conclusion：The functional connectivity changes between the amygdala and multiple cerebral cortexs might be a potential biomarker for evaluating the progression of aMCI.