嗜麦芽窄食单胞菌感染的临床分布及耐药性分析

目的了解嗜麦芽窄食单胞菌的临床分布,分析细菌的耐药谱,为临床选择抗菌药物提供药敏监测资料。方法经VITEK系统鉴定的嗜麦芽窄食单胞菌96株,进行自动化、纸片扩散K—B法药敏试验,分析其感染分布及耐药性变化。结果在临床分离的嗜麦芽窄食单胞菌标本中,以痰液为主（72．9％）,其次为咽拭子和创口分泌物;该菌对大多数抗菌药物耐药,但对米诺环索、左氧氟沙星、复方新诺明和头孢哌酮,舒巴坦的耐药率较低,分别为4．5％、14．6％、18．8％和21．1％。结论嗜麦芽窄食单胞菌以下呼吸道感染多见,临床治疗应注意合理使用抗菌药物、加强耐药性监测。

Analysis of Clinical Distribution and Drug Resistance of Stenotrophomonas Maltohpilia Infection

Objective To investigate the cl inical distribution of stenotrophomonas mahohpilia （SMA）, analyze the drug resistance （MDR） of SMA, and provide data of drug sensitivity analysis for clinical use of antibiotics. Methods 96 strains of SMA were identified by VITEK system. The drug sensitivity test of SMA was carried out by K-B disc diffusion method automatically, and the distribution and MDR of SMA were analyzed. Results The clinical SMA specimens mainly came from sputum （72.9%）, secondly from throat swab and wound secretion. SMA is resistant to most of the antibiotics, whereas had low overall resistant rate to minocycline, levofloxacin, compound sulfamethoxazole and sulperazon, which were 4.5%, 14.6%, 18.8% and 21.1%, respectively. Conclusions Most of SMA infections occurred in lower respiratory tract. To prevent and treat the infection of SMA, the rational use of antibiotics and MDR monitoring should be strengthened.