骨质疏松老年大鼠正畸牙移动实验

目的研究骨质疏松对老年大鼠牙移动的影响。方法82只三月龄雌性未育健康SD大鼠随机分为骨质疏松组和健康对照组（各42只）；每组大鼠再随机分为0、1、3、5、7、10和14d加力组。测量不同加力时间段牙移动距离，切片HE染色观察组织学变化、抗酒石酸酸性磷酸酶（TRAP）酶组织化学染色计数破骨细胞。结果骨质疏松组牙移动速度和移动距离都大于对照组（P〈0．05），骨质疏松大鼠牙移动第一快速期比对照组长，且移动距离更大，停滞期比对照组短。破骨细胞数量和转化聚集速度大于对照组（P〈0．05）。结论骨质疏松会加速老年大鼠牙移动。

Effects of Osteoporosis on Experimental Tooth Movement in Aged Rats

Objective To examine the experimental tooth movement and recruitment of new osteoclasts in aged variotomized(OVX) rats. Methods Eighty-two 3-month female virgin health rats were divided into two groups. Each group was divided into seven sub-groups of tooth movement: 0,1,3,5,7,10 and 14 days. The tooth movement and the population of osteoclasts were measured and comparatively analyzed. Results The osteoporosis rats showed larger and faster tooth movement(P<0.05). In the osteoporosis group, the instantaneous tooth movement lasted longer time and traversed larger distance, the delay period was shorter, the population of osteoclasts was larger and displayed a faster recruitment. Conclusion These findings indicate that osteoporosis accelerates tooth movement in aged OVX rats.