|
|||||
|
|
| 串珠镰刀菌素致软骨细胞损伤及硒保护作用的实验研究 | |
| 引用本文： | 徐艺,王治伦,曹峻玲,代晓霞,谭希旺,耿冬. 串珠镰刀菌素致软骨细胞损伤及硒保护作用的实验研究[J]. 中国地方病防治杂志, 2001, 16(2): 68-71 |
| 作者姓名： | 徐艺 王治伦 曹峻玲 代晓霞 谭希旺 耿冬 |
| 作者单位： | 西安交通大学地方病研究所,西安,710061 |
| 基金项目： | 卫生部科学研究基金!96－1－252，陕西省社会发展计划项目!96K12－G12，陕西省自然科学研究计划项目! 97SM52 |
| 摘 要： | 本实验以串珠镰刀菌素MON和硒Se共同作用于体外培养的软骨细胞，观察其对软骨细胞及其质代谢的影响，结果显示：加MON0.4,0.7,1.0MG/l组，随着毒素浓度的增加，软骨细胞损伤加重，DNA合成和细胞分裂分裂增殖能力减低，细胞膜流动性逐渐降低，基质中葡萄糖醛酸含量逐渐减少，加Se0.5mg/L后以上影响有所减弱，但不能阻止损伤的发生，光学显微镜下观察各组细胞变化不大，电镜下毒素组细胞损伤伤明显，与对照组有显差别。 |
| 关 键 词： | 串珠镰九菌素 硒 软骨细胞培养 软骨细胞损伤 实验 大骨节病 |
| 修稿时间： | 2000-09-22 |
The experimental study of the damage of moniliformin and the protective effect of selenium on chondrocytes |
|
| Xu Yi,Wang Zhilun,Cao Junling,et al. The experimental study of the damage of moniliformin and the protective effect of selenium on chondrocytes[J]. Chinese Journal of Control of Endemic Disenaces, 2001, 16(2): 68-71 | |
| Authors: | Xu Yi Wang Zhilun Cao Junling et al |
| Abstract: | The present study aims to observe the effect of moniliformin toxicity and selenium supplement on the cultured chondrocytes in vitro. The results showed that moniliformin had a significant effect to damage the cultured chondrocytes. It can decrease the DNA synthesis and the cell division and proliferation,as well as cut down membrane flurioty. It was also reduced the contents of GlcUA in tea intercellular matrix. It can lead to abnormal alternation on ultrastructure and morphologic structure. Selenium supplement had a slight influence. |
| Keywords: | Moniliformin Selenium Chondrocyte cell culture |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |