毛果芸香碱防止Nd∶YAG激光虹膜切除术后眼压升高

目的:了解毛果芸香碱是否能有效降低棕色虹膜人种激光虹膜切除术后眼压急性升高。方法:原发性闭角型青光眼48例58眼,按年龄、性别进行匹配,分为治疗组和对照组。治疗组术前30min和术后即刻滴用20g/L毛果芸香碱,对照组滴用安慰剂。术后0.5,1.0,1.5,2.0,3.5h观察眼压和其他情况。结果:激光治疗后,治疗组和对照组眼压最大升高值分别为0.62±0.67kPa(1kPa=7.5mmHg)和1.13±0.87kPa,两组间差异有显著性(P=0.03)。治疗组的眼压明显下降发生于Nd∶YAG激光虹膜切除术后0.5,1.0和1.5h。除治疗组激光虹膜切除术后瞳孔直径明显小于对照组外,未见其他眼部和全身的副作用。结论:20g/L毛果芸香碱在棕色人种中可以有效地防止Nd∶YAG激光虹膜切除术后眼压升高。

Increase of intraocular pressure after Nd:YAG laser iridectomy interruped by pilocarpine

·AIM:To investigate if pilocarpine can effectively prevent the acute increase of intraocular pressure(IOP)in brown eyes after Nd∶YAG laser iridectomy.·METHODS:Totally 48 cases 58 eyes with primary angle-closure glaucoma were divided into treatment and control groups,which were matched by age and sex.One drop of pilocarpine was applied into the conjunctival sac at one hour before laser iridectomy and immediately after laser iridectomy in treatment group,whereas one drop of antibiotic as placebo was applied in control group at the same time.IOP,pupil diameter were measured at 0.5,1.0,1.5,2.0,3.5 hours after laser iridectomy.·RESULTS:The maximum increase of IOP after laser iridectomy was 0.62±0.67kPa and 1.13±0.87kPa in treatment and control group respectively,there was a significant difference(P=0.03).The obvious decrease of IOP occurred at 0.5,1.0 and 1.5 hours after laser iridectomy in treatment group.No ocular and systemic side effects were found in treatment group,except pupil diameter was obviously larger in treatment group than that in control group.·CONCLUSION:20g/L pilocarpine can effectively prevent the acute increase of IOP in brown eyes after Nd∶YAG laser iridectomy.·