| 英夫利西单抗治疗难治性重症类风湿关节炎临床研究 |
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| 引用本文： | 谢希,陈进伟,高洁生,李芬,田静,杜金烽,王静,毛妮. 英夫利西单抗治疗难治性重症类风湿关节炎临床研究[J]. 中国新药杂志, 2010, 0(4) |
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| 作者姓名： | 谢希 陈进伟 高洁生 李芬 田静 杜金烽 王静 毛妮 |
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| 作者单位： | 中南大学湘雅二医院风湿免疫科; |
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| 摘 要： | 目的:观察英夫利西单抗(infliximab)治疗难治性重症类风湿关节炎(RA)8周的临床疗效及不良反应。方法:10例难治性重症RA患者接受英夫利西单抗治疗(0周,第2周,第6周),观察治疗前、第1周、第4周及第8周各项观察指标变化,并记录不良反应发生情况。结果:10例RA患者临床指标、实验室指标及DAS28评分均有显著改善(P<0.05),未见明显不良反应。结论:英夫利西单抗能在短时间内迅速改善难治性重症RA的各项症状、体征和实验室炎性活动指标,显著改善病情。
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| 关 键 词： | 类风湿关节炎 疗效 英夫利西单抗 |
Clinical research of infliximab in patients with severe refractory rheumatoid arthritis |
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| XIE Xi,CHEN Jin-wei,GAO Jie-sheng,LI Fen,TIAN Jing,DU Jin-feng,WANG Jing,MAO Ni. Clinical research of infliximab in patients with severe refractory rheumatoid arthritis[J]. Chinese Journal of New Drugs, 2010, 0(4) |
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| Authors: | XIE Xi CHEN Jin-wei GAO Jie-sheng LI Fen TIAN Jing DU Jin-feng WANG Jing MAO Ni |
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| Affiliation: | XIE Xi,CHEN Jin-wei,GAO Jie-sheng,LI Fen,TIAN Jing,DU Jin-feng,WANG Jing,MAO Ni(Department of Rheumatology,The Second Xiangya Hospital,Central South University,Changsha 410011,China) |
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| Abstract: | Objective:To evaluate 8-week effects and adverse reactions of infliximab in patients with severe refractory rheumatoid arthritis(RA).Methods: Ten patients with severe refractory RA were treated with infliximab(weeks 0,2 and 6),and clinical,laboratory and psychological indices were recorded 1,4,and 8 weeks after treatment.Results: The clinical,laboratory indices and DAS28 score observed in all of the patients were significantly improved(P<0.05),and no obvious adverse reactions were observed.Conclusion: Infli... |
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| Keywords: | rheumatoid arthritis efficacy infliximab |
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