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| 复方消炎凝胶剂的研制和质量控制 | |
| 引用本文： | 王晓敏 郭平. 复方消炎凝胶剂的研制和质量控制[J]. 华西药学杂志, 1998, 13(3): 185-187 |
| 作者姓名： | 王晓敏 郭平 |
| 作者单位： | 华西医科大学口腔医学院!成都，610041(王晓敏，马丽萍)，华西医科大学药学院!成都，610041(郭平)，华西医科大学制药厂!成都，610041(王丹)，华西医科大学附属第四医院!成都，610041(周天杰) |
| 摘 要： | 用卡波姆－９４０为基质，０．３％氧氟沙星和０．５％甲硝唑制备复方凝胶剂，在制剂的质量控制中，采用上吸收双波长法和选用２９３、２５９、２７６、３１０ｎｍ同时测定其吸光度值Ａλ，消除干扰和测定氧氟沙星及甲硝唑的含量。该复方凝胶制剂制备工艺简便，药物释放速率适中，质量控制简便易行。 |
| 关 键 词： | 凝胶剂 氧氟沙星 甲硝唑 质量控制 |
PREPARATION OF COMPOUND GEL CONTAINING OFLOXACIN AND METRONIDAZOLE AND ITS QUALITY CONTROL |
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| Wang Xiaoming,Guo Ping,Wang Dan, Zhou Tianjie, Ma Liping. PREPARATION OF COMPOUND GEL CONTAINING OFLOXACIN AND METRONIDAZOLE AND ITS QUALITY CONTROL[J]. West China Journal of Pharmaceutical Sciences, 1998, 13(3): 185-187 | |
| Authors: | Wang Xiaoming Guo Ping Wang Dan Zhou Tianjie Ma Liping |
| Abstract: | The Compound gel containing 0. 3%Ofloxacin and 0. 5% Metronidazloe was prepared by using hydrohilic gel of carbomer 940 as matrix.The process was simple and easy to perform. The wavelengths of 293, 259, 276, 310nm were chosen to be mesured for their absorption and the method of isoabsorption at biwavelength was used to eliminate the interferences in the determination of Ofloxacin and Metronidazole during the quality control. The rate of drugs release from the gel was slower by comparing to that of their solution. |
| Keywords: | Gel Ofloxacin Metronidazole Release |
| 本文献已被 CNKI 维普 等数据库收录！ | |