Functional organization of the fusiform gyrus revealed with connectivity profiles |
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| Authors: | Wen Zhang Jiaojian Wang Lingzhong Fan Yuanchao Zhang Peter T. Fox Simon B. Eickhoff Chunshui Yu Tianzi Jiang |
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| Affiliation: | 1. Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;2. School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA;3. Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China;4. Research Imaging Institute, University of Texas Health Science Center at San Antonio, Texas;5. Institute of Neuroscience and Medicine (INM‐1), Research Centre Jülich, Germany;6. Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Dusseldorf, Germany;7. Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China;8. National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;9. The Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia;10. CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China |
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| Abstract: | Within the object recognition‐related ventral visual stream, the human fusiform gyrus (FG), which topographically connects the striate cortex to the inferior temporal lobe, plays a pivotal role in high‐level visual/cognitive functions. However, though there are many previous investigations of distinct functional modules within the FG, the functional organization of the whole FG in its full functional heterogeneity has not yet been established. In the current study, a replicable functional organization of the FG based on distinct anatomical connectivity patterns was identified. The FG was parcellated into medial (FGm), lateral (FGl), and anterior (FGa) regions using diffusion tensor imaging. We validated the reasonability of such an organizational scheme from the perspective of resting‐state whole brain functional connectivity patterns and the involvement of functional subnetworks. We found corroborating support for these three distinct modules, and suggest that the FGm serves as a transition region that combines multiple stimuli, the FGl is responsible for categorical recognition, and the FGa is involved in semantic understanding. These findings support two organizational functional transitions of the ventral temporal gyrus, a posterior/anterior direction of visual/semantic processing, and a media/lateral direction of high‐level visual processing. Our results may facilitate a more detailed study of the human FG in the future. Hum Brain Mapp 37:3003–3016, 2016. © 2016 Wiley Periodicals, Inc . |
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| Keywords: | parcellation fusiform gyrus functional characterization resting‐state tractography |
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