| 人类乳头状瘤病毒与肺癌的病因关系研究(三) |
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| 引用本文： | 杨渝浩,董德琼,彭理年,肖瑜,庄恒国. 人类乳头状瘤病毒与肺癌的病因关系研究(三)[J]. 贵州医药, 2001, 25(11): 973-974 |
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| 作者姓名： | 杨渝浩 董德琼 彭理年 肖瑜 庄恒国 |
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| 作者单位： | 遵义医学院附属医院呼吸内科,;遵义医学院附属医院检验科,;遵义医学院附属医院病理教研室, |
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| 基金项目： | 贵州省教委资助课题 (C 0 98) |
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| 摘 要： | 目的：继续研究人乳头瘤病毒与肺癌的病因关系。方法：采用多重聚合酶链反应（PCR）技术,对7种肺组织进行HPV8、HPV18及HPV35型检测。结果：在鳞癌及其邻近鳞状化生上皮中,HPV18和HPV35的检出率无明显差异,肺鳞癌和腺癌中,两者亦无明显差异,在肺鳞癌和正常支气管粘膜中HPV18的检出率却有显著差异（P＜0．01）。结论：HPV18和HPV35型感染与肺鳞癌和腺癌的发生有关,HPV18更具危险性。
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| 关 键 词： | 人乳头状瘤病毒 肺肿瘤 聚合酶链反应 |
The etiologic relationship of HPV infection to the development of lung cancer |
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| Yang Yuhao,Dong Deqiong,Pen Linian,et al.. The etiologic relationship of HPV infection to the development of lung cancer[J]. Guizhou Medical Journal, 2001, 25(11): 973-974 |
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| Authors: | Yang Yuhao Dong Deqiong Pen Linian et al. |
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| Affiliation: | Yang Yuhao,Dong Deqiong,Pen Linian,et al. Department of Respiratory Medicine,The Affiliated Hospital of Zunyi Medical College,Zunyi 563003 |
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| Abstract: | Objective To study the etiologic relationship of HPV infection to the development of lung cancer. Methods Seven tissues of lung were searched for the presence of HPV subtypes 8?18 and 35 by PCR. Results The detected rates of HPV18 and HPV35 had no significant difference ( P >0.05) between squamous cell carcinoma (SQ) and the squamous epithelium metaplasia adjacent tumors, and between SQ and adnocarcionma (AC). But, the detected rates of HPV18 had a significant difference ( P <0.01) between SQ and normal bronchial mucosa. Conclusion HPV18 and HPV35 infection contribute to the development AC and SQ of lung . The HPV18 could have a more high risk. |
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| Keywords: | Human papillomavirus Lung neoplasmas Polymerase chain reaction |
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