中国某县有偿献血员艾滋病病毒感染流行病学研究

目的：了解中国有偿献血员ＨＩＶ感染率及其流行因素。方法：对中国中部某县两个村１８￣５０岁村民进行ＨＩＶ感染率调查，并进行定群研究。结果 １９９７年调查了９６３人，发现ＨＩＶ抗体阳性者１７例，ＨＩＶ感染率为１．８％，其中有偿献血员８８人，１５例为ＨＩＶ抗体阳性，ＨＩＶ感染率为１７．０％，显著高于非献血人群（０．２％）。１９９８年和２０００年进行了随访，其中ＨＩＶ抗体阴性人群６６８人，共随访１７４２人

The epidemiological study of HIV infection among paid blood donors in one county of China

OBJECTIVE: To observe the prevalence of HIV infection among paid blood donors and risk factors. METHODS: Selected the residents between 18 to 50 years old from two villages in one county of China in 1997. We observed the prevalence of HIV infection and keep following them to 2000. RESULTS: Nine hundred sixty-three residents were investigated and the prevalence of HIV was 1.8% (17/963). There were 88 paid blood donors among 963 interviewed subjects, the HIV prevalence was significantly higher (17.0% or 15/88) than those who didn't have the experiences of paid blood donations (0.2% or 2/875). Only one person out of 668 who were followed from 1997 to 2000 has converted to sero-positive, the incidence of HIV infection is 0.06 per 100 person-years. Nearly half of sero-negative and sero-positive people have the experiences of muscle injection. Among those with HIV-positive spouse, we found no one converted to sero-positive. The CD(4) count of those sero-positive people declined every year. HIV subtype and C2-V3 region sequence analysis were made for five HIV-positive people in 1998, the result indicated that all of them were infected with HIV-1 subtype B' and the genetic divergence rate was 2.4%. CONCLUSION: There was a high prevalence of HIV among paid blood donors in some regions, and paid blood (plasma) donations were the main risk factor for HIV infection. Although no evidence suggests that during the follow-up period the epidemic of HIV infection has spread locally, it still shall take measurements to prevent further transmission of HIV through paid blood donors.