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| 急性冠脉综合征患者血清MMP-2、MMP-9及IL-6水平的检测及其临床意义 | |
| 引用本文： | 王政,赵会忠,陈红丽,周海舟,田学峰. 急性冠脉综合征患者血清MMP-2、MMP-9及IL-6水平的检测及其临床意义[J]. 中国当代医药, 2014, 0(22): 4-6 |
| 作者姓名： | 王政 赵会忠 陈红丽 周海舟 田学峰 |
| 作者单位： | 王政(黑龙江省医院心内科,哈尔滨,150036)； 赵会忠 (黑龙江省饶河县中医院心内科,黑龙江饶河,155700)； 陈红丽 (哈尔滨医科大学附属第一医院护理质控办公室,哈尔滨,150001)； 周海舟 (哈尔滨医科大学附属第一医院检验科,哈尔滨,150001)； 田学峰(黑龙江省医院心内科,哈尔滨,150036)； |
| 基金项目： | 黑龙江省教育厅科学技术研究项目(11531130)；黑龙江省卫生厅科研课题(项目编号：2007166) |
| 摘 要： | 目的：检测急性冠脉综合征（ACS）患者血清中基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）及白介素-6（IL-6）的水平及相关性并评价其临床意义。方法选取ACS患者106例分成3组,其中USAP组42例、NSTEMI组34例、STEMI组30例。用酶联免疫吸附试验（ELISA）检测所有患者MMP-2、MMP-9及IL-6水平,并用Real-Time PCR检测血清中MMP-2和MMP-9蛋白水平。结果3组患者与对照组相比,MMP-2、MMP-9和IL-6检测水平均明显增高,其中STEMI组患者MMP-2和MMP-9比其他两组增高明显。3组患者的IL-6水平比较差异无统计学意义。 ACS患者IL-6与MMP-2和MMP-9呈正相关（r=0.547、0.478,P〈0.01）。结论MMP-2、MMP-9和IL-6在ACS中高表达,可作为预测动脉硬化斑块不稳定或破裂的血清学指标,其水平有利于冠心病患者的危险分级。 |
| 关 键 词： | 急性冠脉综合征 基质金属蛋白酶-2 基质金属蛋白酶-9 白介素-6 |
The level of MMP-2,MMP-9 and IL-6 with acute coronary syndrome and its clinical significance |
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| Affiliation: | WANG Zheng, ZHAO Hui-zhong, CHEN Hong-li, ZHOU Hai-zhou, TIAN Xue-feng (1.Department of Cardiology,Heilongjiang Provincial Hospital,Harbin 150036,China;2.Department of Cardiology,Hospi- tal of Traditional Chinese Medicine of Raohe County in Heilongjiang Province,Raohe 155700,China;3.Nursing Quality Control Office,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;4.Department of Labo- ratory,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China) |
| Abstract: | Objective To detect the level of MMP-2,MMP-9 and IL-6 with acute coronary syndrome（ACS）,and to eval-uate their clinical significance. Methods 106 cases of patients with ACS were selected and divided into USAP group （n=42）,NSTEMI group （n=34）and STEMI group （n=30）.The level of MMP-2,MMP-9 and IL-6 were determined by en-zyme linked immunosorbent assay （ELISA）.The protein level of MMP-2 and MMP-9 were determined by Real-Time PCR. Results Compared with control group,the level of MMP-2 and MMP-9 increased strongly in the other three groups respectively.Compared with STEMI group,the level of MMP-2 and MMP-9 increased strongly in the other two groups respectively.The level of IL-6 in three groups was compared,with no statistical difference.There was a positive correlation between IL-6 and MMP-2,MMP-9 respectively （r=0.547,0.478,P〈0.01）. Conclusion The MMP-2,MMP-9 and IL-6 are highly expressed in ACS.The level of serum MMP-2,MMP-9 and IL-6 can be regarded as serum indices to judge unstable or ruptured plaque,and this is good for coronary heart disease degree. |
| Keywords: | Acute coronary syndrome MMP-2 MMP-9 IL-6 |
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