| 糖化血红蛋白与冠状动脉病变特点相互关系的研究 |
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| 引用本文： | 冯新星,吴亚杰,宋莹,王东,张茵,陈伊,王怡璐,王继征,巩秋红,邹玉宝,宋雷,袁晋青,孙凯,陈燕燕. 糖化血红蛋白与冠状动脉病变特点相互关系的研究[J]. 中国分子心脏病学杂志, 2013, 0(6): 711-713 |
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| 作者姓名： | 冯新星 吴亚杰 宋莹 王东 张茵 陈伊 王怡璐 王继征 巩秋红 邹玉宝 宋雷 袁晋青 孙凯 陈燕燕 |
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| 作者单位： | [1]中国医学科学院、北京协和医学院、国家心血管病中心、阜外心血管病医院内分泌科 [2]阜外心血管病医院心内科 [3]阜外心血管病医院心外科恢复室 [4]心血管疾病国家重点实验室 |
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| 基金项目： | 973计划项目（2010CB732601）院所青年基金支持项目（2013-F10） |
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| 摘 要： | 目的探讨糖化血红蛋白与冠状动脉病变特点的相互关系。方法人选在我院住院的患者1375例，检测糖化血红蛋白，并行冠脉造影术，以Gensini评分评价患者冠状动脉狭窄程度，冠脉病变特点以冠脉病变支数及冠脉狭窄程度来表示。结果糖化血红蛋白与冠脉病变支数显著相关。糖化血红蛋白与Gensini积分呈正相关。在校正了年龄、性别、体重指数、吸烟、饮酒、收缩压、舒张压、肌酐、尿酸、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三脂、空腹血糖、高敏C反应蛋白等危险因素后，糖化血红蛋白与Gensin积分的相关性仍存在。结论糖化血红蛋白升高与冠脉狭窄程度加重相关，同时与累及的冠脉支数增加相关。
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| 关 键 词： | 糖化血红蛋白 冠状动脉 病变特点 相互关系 |
The relationship between HbAlc and characteristics of coronary artery lesions |
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| Feng Xin-xing,Wu Ya-jie,Song ling,Wang Dong,Zhang lin,Chen Yi,Wang li-lu,Wang Ji-zheng,Gong Qiu-hong,Zou Yu-bao,Song Lei,Yuan Jin-qing,Sun Kai,Chen Yan-Yan. The relationship between HbAlc and characteristics of coronary artery lesions[J]. Molecular Cardiology of China, 2013, 0(6): 711-713 |
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| Authors: | Feng Xin-xing Wu Ya-jie Song ling Wang Dong Zhang lin Chen Yi Wang li-lu Wang Ji-zheng Gong Qiu-hong Zou Yu-bao Song Lei Yuan Jin-qing Sun Kai Chen Yan-Yan |
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| Affiliation: | . (State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China) |
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| Abstract: | Objective This study is to investigate the relationship between HbAlc and the characteristics of coronary artery lesions. Methods A total of 1375 patients who were suspected coronary artery disease were enrolled. All these patients underwent coronary artery angiography. HbA 1 c also was inspected. The characteristics of coronary artery lesions were assessed by severity of coronary artery stenosis and the number of coronary vessels with stenosis. Results HbA 1 c significantly correlates with the number of coronary vessels with stenosis. There is a positive correlation between HbAlc and the Gensini score. After adjustment for age, sex, BMI, smoking, drinking, SBP, DBP ,Cr ,UA, CHOL, TG, LDL-C, HDL-C, FBG and HsCRP, HbAlc still correlates with gesini score. Conclusion The increasing of HbAlc correlates with severity of the coronary artery stenosis and the number of coronary vessels with stenosis. |
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| Keywords: | HbAlc coronary artery Characteristics of lesions Relationship |
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