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| HBsAg阴性乙型肝炎患者血清HBV-DNA检测的临床意义 | |
| 引用本文： | 闵贤,陆北川,黎海苓,贾辅忠. HBsAg阴性乙型肝炎患者血清HBV-DNA检测的临床意义[J]. 南京医科大学学报(自然科学版), 1986, 0(4) |
| 作者姓名： | 闵贤 陆北川 黎海苓 贾辅忠 |
| 作者单位： | 南京医学院第一附属医院传染病科，南京医学院第一附属医院传染病科，南京医学院第一附属医院传染病科，南京医学院第一附属医院传染病科 |
| 摘 要： | 应用斑点杂交方法对36例HBsAg阴性的各种类型的乙型肝炎患者进行了血清HBV-DNA的检测,33例获得阳性结果。目前认为血清和肝组织HBV-DNA的检测是判断HBV感染和复制的特异和敏感方法,对于HBV感染的临床诊断和流行病学的研究有一定意义。 |
| 关 键 词： | 乙型肝炎 肝炎 病毒性 人 HBsAg HBV-DNA 斑点杂交试验 |
HEPATITIS B VIRUS DNA IN PATIENTS WITH HEPATITIS B AND NEGATIVE TEST FOR HEPATITIS B SURFACE ANTIGEN |
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| Min Xian,et al.. HEPATITIS B VIRUS DNA IN PATIENTS WITH HEPATITIS B AND NEGATIVE TEST FOR HEPATITIS B SURFACE ANTIGEN[J]. Acta Universitatis Medicinalis Nanjing, 1986, 0(4) | |
| Authors: | Min Xian et al. |
| Abstract: | we assessed the presence of HBV DNA in serum samples from 36 patients HBsAg-negative hepatitis B by spot hybridization test with cloned HBV DNA probe.This study demonstrated the high frequency of HBsAg-negative HBV DNA positive viral infection of the liver and suggests that multiplication HBV might occur in the absence of any conventional serologic marker for HBV.HBV DNA sequences are present in the liver or serum in the absence of serologic markers of a recent ot past contact with HBV.This suggests either the absence or partial expression of the HBV genes in the oliver or the absence of a humoral immune response to the su face and the core antigen. |
| Keywords: | Hepatitis B Hepatitis viral human Hepatitis B surface antigens HBV-DNA Spot hybridization test |
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