原发性高血压病和2型糖尿病血瘀证与非血瘀证患者抵抗素、脂联素水平比较

目的探讨原发性高血压病和2型糖尿病患者抵抗素、脂联素与血瘀证的关系。方法以原发性高血压和糖尿病患者为对象,空腹取静脉血制备血浆、血清,酶免法检测血清脂联素、抵抗素,放免法检测血清瘦素、胰岛素和血浆内皮素、肿瘤坏死因子,酶法检测血清血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇。使用SAS9.1 for windows分析各项指标与血瘀证的关系。结果糖尿病组血瘀证检出率0.423,高血压病组为0.246,差异有统计学意义;血瘀证检出率随着病程延长而增高。与非血瘀证组比较,血瘀证组瘦素、内皮素、肿瘤坏死因子水平升高,脂联素、胰岛素水平降低,血清抵抗素差异无统计学意义。与原发性高血压病患者比较,2型糖尿病患者抵抗素、脂联素、瘦素、胰岛素水平均升高,而内皮素、肿瘤坏死因子差异无统计学意义。结论脂联素与血瘀证形成负相关;肥胖致瘀可能是由脂肪因子调节血管活性因子实现的;肥胖性血瘀可能与抵抗素水平无关。

Comparative Study on the Level of Resistin, Adiponectin between Blood Stasis Syndrome and Non-Blood Stasis Syndrome in Diabetic and Primary Hypertension Patients

Objective To investigate the correlation between resistin, adiponectin and the blood stasis syndrome in diabetic and primary hypertension patients. Method The primary hypertension and diabetes patients were drawn vein blood to make plasma and serum. Enzyme linked immunosorbent assay （ELISA） method was used in checking serum adiponectin and resistin. Radioimmuoassay method was applied in checking serum insulin, leptin, ET and tumor necrosis factor （TNF）. The fasting blood sugar, total cholesterol （TC）, triamid-glycerin （TG）, high dense lipoprotein-cholesterol （HDL） and low dense lipoproteincholesterol （LDL） were detected by the chemi-enzymic method. The relation between the indexes and blood stasis syndrome was analyzed by SASg. 1 for windows. Results The detectable rate of the blood stasis syndrome in the diabetic patients was 0.423, while 0.246 in the primary hypertension patients. The difference was significant in statistics. Incidence of blood stasis syndrome increased with the course of illness. Compared with the non-blood stasis syndrome group, the content of leptin, ET and TNF in the blood stasis syndrome group significantly raised, but the content of adiponectin and insulin diminished. The content of resistin did not have obviously change. Compared with the primary hypertension patients, the level of leptin, adiponectin, resistin, insulin in the diabetic patients raised, but there wasn＇t significant difference in the level of ET and TNF. Conclusions There is negative correlation between adiponectin and the blood stasis syndrome. The link between obesity and the blood stasis syndrome may be through fat factor regulating vasoactive factor. The blood stasis syndrome caused by obesity maybe have nothing to do with the consistency of resistin.