2型糖尿病患者大血管病变相关因素研究

目的检测2型糖尿病（T2DM）患者外源性血浆凝血因子Ⅶ（FⅦ）、内源性血浆凝血因子Ⅷ（FⅧ）、血浆纤维蛋白原（Fib）、三酰甘油（TG）等指标的水平,探讨其与糖尿病大血管病变（DMAP）的关系,为监测DMAP的发生和将来可能针对此环节实施的预防措施提供必要的理论依据。方法T2DM患者以大血管病变程度进行临床分组：重度DMAP（sDMAP）组、轻度DMAP（mDMAP）组、无DMAP（Non-DMAP）组,并设健康对照组,对4组FⅦ、FⅧ、Fib、TG水平及吸烟人数比例等指标进行比较。结果T2DM患者FⅦ、FⅧ、Fib、TG水平及吸烟人数比例高于健康对照组（P〈0.05或〈0.01）;mDMAP组和sDMAP组高于Non-DMAP组（P〈0.01或〈0.05）;sDMAP组高于mDMAP组（P〈0.05）。多因素Logistic回归分析表明FⅦ、FⅧ、Fib和TG、吸烟是DMAP的独立危险因素。结论FⅦ、FⅧ、Fib、TG水平及吸烟人数比例是T2DM及DMAP病变程度的独立危险因素。

Study on the related factors with macroangiopathy in patients with type 2 diabetes mellitus

Objective To detect the levels of plasma cruor factor Ⅶ （FⅦ） , plasma cruor factor Ⅷ（F Ⅷ）, fibrinogen （Fib）, triglyceride （TG） in order to investigate the relationship between these parameters and macroangiopathy （DMAP） in patients with type 2 diabetes mellitus so as to provide medical evidence for monitoring the genesis of DMAP and taking necessary precautionary measures. Methods The patients with type 2 diabetes mellitus were divided into groups according to the severity of DMAP, severe DMAP group（sDMAP） , mild DMAP group （ mDMAP）, Non-DMAP group and control group （ healthy subjects）. The levels of F Ⅶ, FⅧ, Fib, TG were detected in the four groups and the proportion of smoking people was compared. Results The levels of FⅦ, FⅧ,Fib,TG and the proportion of smoking people in T2DM group were significantly higher than those of control group（ P 〈0.05 or 〈0.01 ） ; which in mDMAP group and sDMAP group were significantly higher than those in Non-DMAP group（ P 〈0.05 or 〈 0. 01 ）; which in sDMAP group were obviously higher than those in mDMAP group（ P 〈0.05 or 〈 0.01 ）. Multiple factor Logistic regression analysis showed that FⅦ, Ⅷ, Fib, TG and smoking were the independent risk factors of DMAP. Conclusion The levels of FⅦ, FⅧ, Fib, TG and proportion of smoking people are the independent risk factors for DMAP.