非乙醇性脂肪性肝病的药物治疗

非乙醇性脂肪性肝病已成为一种常见的危害人类健康的疾病,早期可以仅出现肝细胞脂肪变性,进一步可发展为脂肪性肝炎、肝纤维化、肝硬化等终末期病变。胰岛素抵抗和氧化应激在非乙醇性脂肪性肝病的发病机制中有重大意义,大量实验表明,减轻胰岛素抵抗和抗氧化剂治疗非乙醇性脂肪性肝病有效。此外,降脂药物、细胞保护剂等对肝脏病理及血清学指标也有改善,目前尚未发现治疗非乙醇性脂肪性肝病的特效药物。

Drug Therapy for Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease(NAFLD)is now recognized as the most common liver disease which does harm to people's health in the world.In its initial phases,liver cells only show up fatty degeneration.In advanced stages,fatty hepatitis,hepatic fibrosis and hepatic cirrhosis will occur.Insulin resistance and oxidative stress play the important role in the pathogenesis of nonalcoholic fatty liver disease.And many experiments show reducing Insulin resistance and antioxidant are useful to treatment NAFLD.In ...