| 依达拉奉联用降纤酶治疗急性脑梗死临床研究 |
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| 引用本文： | 龙威,谢娟,唐建国,张羽,张奕翠,陆刚,陆伟.依达拉奉联用降纤酶治疗急性脑梗死临床研究[J].中国实用内科杂志,2008(Z1). |
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| 作者姓名： | 龙威 谢娟 唐建国 张羽 张奕翠 陆刚 陆伟 |
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| 作者单位： | 复旦大学附属上海市第五人民医院急诊科; |
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| 摘 要： | 目的研究依达拉奉联用降纤酶治疗急性脑梗死的临床疗效及安全性。方法选择2005—2007年复旦大学附属上海市第五人民医院急诊科发病12h内的急性脑梗死患者93例,随机分为A组46例和B组47例。A组患者使用依达拉奉注射液(30mg加入生理盐液100mL静脉滴注,每日2次,共14d)和降纤酶(首剂量为15U,以后隔日5U,共4次,均加入生理盐液250mL,2～3h内静脉滴注);B组仅使用降纤酶治疗。治疗前后对患者进行欧洲脑卒中量表(ESS)神经功能缺损程度评分、日常生活能力(ADL)、APACHEⅡ评分及C-反应蛋白(CRP)的测定,治疗后进行疗效评定,进行为期3个月的随访。结果在治疗后14d,两组患者的ESS、ADL、A-PACHEⅡ和CRP较治疗前有显著改善,A组的各项指标优于B组;A组有效率(67.4%)高于B组(40.4%)(P<0.05);两组的3个月病死率没有显著差异(P>0.05);两组患者均无颅内出血发生,少数患者发生颅外出血,两组没有显著差异,所有病例无严重不良反应发生。结论依达拉奉联用降纤酶能够安全有效的治疗急性脑梗死患者。
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| 关 键 词： | 依达拉奉 降纤酶 急性脑梗死 |
Clinical study of edaravone-defibrase combination in treatment of acute cerebral infarction |
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| LONG Wei,XIE Juan,TANG Jian-guo,ZHANG Yu,ZHANG Yi-cui,LU Gang,LU Wei.Clinical study of edaravone-defibrase combination in treatment of acute cerebral infarction[J].Chinese Journal of Practical Internal Medicine,2008(Z1). |
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| Authors: | LONG Wei XIE Juan TANG Jian-guo ZHANG Yu ZHANG Yi-cui LU Gang LU Wei |
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| Institution: | LONG Wei,XIE Juan,TANG Jian-guo,ZHANG Yu,ZHANG Yi-cui,LU Gang,LU Wei.Department of Emergency,Shanghai Fifth People\'s Hospital,Fudan University,Shanghai 200240,China |
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| Abstract: | Objective To investigate the efficacy and safety of edaravone-defibrase combination in treatment of acute cerebral infarction.MethodsThe patients with acute cerebral infarction within 12 hours of stroke onset were divided randomly into two groups:group A(46 cases)and group B(47 cases).Group A were treated with edaravone(30 mg,twice a day,for 14 days)and defibrase(initial 15U,subsequent 5U on the 3th,5th,7th,9th day);and group B were treated only with defibrase.The neurological deficit scores of European str... |
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| Keywords: | edaravone defibrase acute cerebral infarction |
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