抗氧化酶及脂质过氧化物在肾移植中的意义

检测同种异体肾移植患者的血清抗氧化酶，包括超氧化物歧化酶和谷胱甘肽过氧化物酶及脂质过氧化物的降解产物丙二醛的动态变化。以了解了其在肾缺血－再灌注损伤中的作用。

Effects of antioxidant enzymes and lipioxidation on renal reperfusion injury in the patients with kidney transplantation

To investigate the role of rective oxygen species(ROS)and its scanvenging system on renal reperfusion injury in human beings,the activities of antioxidant enzymes(AOEs)including superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX),and the content of lipioxidatation-malondiadehyde (MDA)were determined in 14 patients before and after renal transplantation.It was found that there were lower activities of serum SOD(P<0.01)and GSH-PX (P<0.01)and an obvious increase of serum MDA content in the patients 1 h before and after renal reperfusion.However,those abnormalities were ameliorated gradually at 4 h,24 h and one week after renal transplantation,associated with the improvement of renal functions.These resuIts indicate that ROS may also contribute to the injury of human renal reperfusion,in which AOEs,one of ROS scanvenging system,play an important protective role in the patients with kidney transplantation.