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| B族维生素治疗肾移植受者高同型半胱氨酸血症 | |
| 引用本文： | 赵敬杰,刘军莉,田川,张彩.B族维生素治疗肾移植受者高同型半胱氨酸血症[J].山东大学学报(医学版),2007,45(8):771-773. |
| 作者姓名： | 赵敬杰 刘军莉 田川 张彩 |
| 作者单位： | 1. 山东大学第二医院临床分子生物学实验室,山东,济南,250033 2. 山东大学第二医院移植中心,山东,济南,250033 3. 山东大学药学院免疫药理与免疫治疗研究所,山东,济南,250012 |
| 摘 要： | 目的：探讨叶酸、维生素B6及B12在治疗肾移植患者高同型半胱氨酸（Hcy）血症中的作用。方法：将195例预接受首次肾移植患者随机分为两组：试验组103例，口服叶酸5mg/d，维生素B6 50mg/d及维生素B12 1mg/d，连续2个月左右；对照组92例则未口服B族维生素。分别于服药治疗前、术前1d、术后1、10、20及30d检测血浆Hcy浓度和血清肌酐水平。结果：试验组血浆Hcy浓度与对照组相比具有统计学意义（P＜0.0001），试验组术后血清肌酐水平下降较快，发生急性排斥反应的比例低于对照组。结论：肾移植患者围手术期适当补充叶酸、维生素B6及B12可降低血浆Hcy浓度，有助于移植肾功能的快速恢复，是减少肾移植并发症及急性排斥反应的重要措施。 |
| 关 键 词： | 同型半胱氨酸 维生素类 肾移植 |
| 文章编号： | 1671-7554（2007）08-0771-03 |
| 收稿时间： | 2007-06-12 |
| 修稿时间： | 2007-06-12 |
Effect of vitamin B on hyperhomocysteinemia in renal-transplant recipients |
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| ZHAO Jing-jie,LIU Jun-li,TIAN Chuan,ZHANG Cai.Effect of vitamin B on hyperhomocysteinemia in renal-transplant recipients[J].Journal of Shandong University:Health Sciences,2007,45(8):771-773. | |
| Authors: | ZHAO Jing-jie LIU Jun-li TIAN Chuan ZHANG Cai |
| Institution: | 1. Laboratory of Clinical Molecular Biology, Second Hospital of Shandong University, Jinan 250033, Shandong, China; 2. Transplant Center, Second Hospital of Shandong University, Jinan 250033, Shandong, China; 3. Institute of Immuno-pharmacology and Immunotherapy, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China |
| Abstract: | Objective: To explore the effect of folic acid,Vit B6,and Vit B12 on hyperhomocysteinemia in renal-transplant recipients.Methods: 195 renal-transplant recipients were randomly divided into the vitamin treatment group(group A,n=103,folic acid 5 mg/d,vitamin B6 50 mg/d,Bl2 1 mg/d,totally 2 months) and the control group(group B,n=92).The plasma Hcy levels were determined before treatment,before operation and 1,10,20 and 30 days after operation.Results: The plasma level of Hcy in group B was significantly higher than that in group A before and after operation.The rate of acute rejection was lower in group A than in group B.Conclusion: Vitamin B supplementation can reduce the homocysteine level and the rate of acute rejection for renal-transplant recipients. |
| Keywords: | Homocysteine Vitamins Kidney transplantation |
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