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血磷对血液透析患者成纤维细胞生长因子23的影响
引用本文:杨涛,蔡美顺,王玉柱,任树风. 血磷对血液透析患者成纤维细胞生长因子23的影响[J]. 中国中西医结合肾病杂志, 2009, 10(9): 776-779
作者姓名:杨涛  蔡美顺  王玉柱  任树风
作者单位:1. 北京市海淀医院肾内科,北京,100044
2. 北京大学人民医院肾内科,北京,100044
摘    要:
目的:检测维持性血液透析(MHD)患者血中成纤维细胞生长因子23(FGF-23)水平,探讨血磷等因素对MHD患者FGF-23的影响。方法:MHD患者67例,对照组肾小球过滤率正常共28例,MHD患者根据血磷水平分为低磷组、血磷达标组和高磷组,酶联免疫吸附法测定血中FGF-23的水平,测定对照组及MHD患者血中碱性磷酸酶、钙、磷水平。结果:MHD组血清FGF-23高于对照组(P〈0.01);低磷组、血磷达标组和高磷组FGF-23水平差异无统计学意义(P〉0.05),高磷组甲状旁腺激素明显高于低磷组及血磷达标组(P〈0.01);单因素直线相关分析未见到血磷与FGF-23的相关性(r=0.018,P〉0.05);多元回归分析显示1,25(OH)2D3是MHD患者FGF-23的影响因素(β=0.521,P〈0.01)。结论:MHD患者血中FGF-23水平明显升高,血磷不是维持性血液透析患者FGF-23升高的影响因素。

关 键 词:血液透析  血磷  成纤维细胞生长因子23

The Effect of Serum Phosphate Level on Fibroblast Growth Factor 23 in Maintenance Hemodialysis Patients
YANG Tao,CAI Meishun,WANG Yuzhu,et alRenal Division. The Effect of Serum Phosphate Level on Fibroblast Growth Factor 23 in Maintenance Hemodialysis Patients[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2009, 10(9): 776-779
Authors:YANG Tao  CAI Meishun  WANG Yuzhu  et alRenal Division
Abstract:
Objective:Serum phosphate level is one of important regulators of fibroblast growth factor(FGF-23)in health adults.We detected the serum phosphate level in maintenance hemodialysis(MHD)patients to observe whether serum phosphate still is a efffect factor on fibroblast growth factor 23.Methods:Sixty seven MHD patients and twenty eight people(control group)whose renal functions were normal were enrolled in this study.According the serum phosphate level,MHD patients were divided into three groups:lower serum p...
Keywords:Hemodialysis  Serum phosphate  Fibroblast growth factor 23(FGF- 23)
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