心房颤动患者血浆D-二聚体与纤维蛋白原变化

目的观察慢性心房颤动(房颤)患者血浆D-二聚体和纤维蛋白原水平的变化,并探讨其意义。方法测量48例房颤患者(其中风心病28例,冠心病20例)和30例正常人血浆D-二聚体(D-dimer)和纤维蛋白原(Fg)。结果房颤患者与正常人相比,血浆D-dimer浓度极显著升高(P<0.01),纤维蛋白原水平也显著升高(P<0.01)。风心病患者与冠心病患者之间D-dimer,Fg差异均无显著性意义(P>0.05)。结论房颤患者血浆D-dimer和Fg水平升高,可能与其高发血栓栓塞并发症有关。

The change of plasma D-dimer and fibrinogen level and its clinical significance in patients with atrial fibrillation

Objective To observe the change of plasma D-dimer and fibrinogen levels in patients with chronic atrial fibrillation, and verify its clinical significance. Methods The plasma levels of D-dimer, fibrinogen (Fg), were measured from 46 patients with atrial fibrillation. 26 patients had rheumatic heart disease (RHD) and another 20 patients had coronary heart disease (CHD). Levels were compared with those found in the plasma of 32 health subjects. Result Patients with atrial fibrillation had higher levels of D-dimer and fibrinogen than controls(P<0.01). No significant differences were found either in PT and APTT between atrial fibillation and controls (P>0.05). No significant differences were found in D-dimer, Fg between rheumatic and nonrheumatic fibrillation (P>0.05). Conclusion The plasma levels of D-dimer and fribinoen in patients with atrial fibrillation are high, which may contribute to increasing risk of thrombosis.