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| 疼痛模型大鼠下丘脑和脊髓CGRP的含量变化 | |
| 引用本文： | 张晓英,杨国栋,余永华,蔡昌平. 疼痛模型大鼠下丘脑和脊髓CGRP的含量变化[J]. 川北医学院学报, 2008, 23(2): 109-111 |
| 作者姓名： | 张晓英 杨国栋 余永华 蔡昌平 |
| 作者单位： | 川北医学院基础医学院解剖学教研室,四川,南充,637000;川北医学院附属医院消化内科,四川,南充,637000 |
| 基金项目： | 川北医学院校级科研基金 |
| 摘 要： | 目的通过测定疼痛模型大鼠下丘脑和脊髓降钙素基因相关肽(calcitonin gene related peptide,CGRP)的含量变化,以探讨疼痛产生机制。方法动物随机分成空白对照组,生理盐水对照组和疼痛模型组,左足跖皮下注射5%甲醛50μl建立大鼠疼痛模型,采用放射免疫分析法测定股动脉血、下丘脑和脊髓中CGRP的含量。结果疼痛模型组SD大鼠血浆中及下丘脑和脊髓CGRP含量分别与空白对照组、生理盐水对照组差别有统计学意义(p<0.05);而空白对照组与生理盐水对照组差别无统计学意义(p>0.05)。结论皮下注射5%甲醛可致疼痛症状产生;提示皮下注射甲醛所致疼痛可引起下丘脑和脊髓组织中的CGRP释放增加,结果导致无菌性炎症反应而引起疼痛症状。 |
| 关 键 词： | 疼痛 降钙素基因相关肽 下丘脑和脊髓 |
| 文章编号： | 1005-3697(2008)02-0109-03 |
| 修稿时间： | 2008-01-12 |
The Change of Content of Calcitonin Gene-related Peptide (CGRP) in Hypothalamus and Spinal Cord of Pain Model Rats |
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| ZHANG Xiao-ying,YANG Guo-dong,SHE Yong-hua,CAI Chang-ping. The Change of Content of Calcitonin Gene-related Peptide (CGRP) in Hypothalamus and Spinal Cord of Pain Model Rats[J]. Journal of North Sichuan Medical College, 2008, 23(2): 109-111 | |
| Authors: | ZHANG Xiao-ying YANG Guo-dong SHE Yong-hua CAI Chang-ping |
| Affiliation: | 1.Department of Anatomy;School of Basic Medicine;North Sichuan Medical College;2.Department of Gastroenterology;Affiliated Hospital of North Sichuan Medical College;Nanchong;Sichuan 637000 |
| Abstract: | Objective To study the change of calcitonin gene-related peptide(CGRP) in hypothalamus and spinal cord of pain model rats.Methods Rats were divided randomly into blank control group,0.9 % NaCl control group and pain model group injected 5% formaldehyde into left baseboard subcutaneously.The immuno-reactive CGRP(iCGRP) in femoral artery,hypothalamus and spinal cord was detected by radioimmunoassay.Results The content of CGRP in femoral artery,hypothalamus and spinal cord was different significantly in pain g... |
| Keywords: | Pain Calcitonin gene-related peptide Hypothalamus and spinal cord |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |