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Hypermutation In Pancreatic Cancer
Authors:Jeremy L. Humphris  Ann-Marie Patch  Katia Nones  Peter J. Bailey  Amber L. Johns  Skye McKay  David K. Chang  David K. Miller  Marina Pajic  Karin S. Kassahn  Michael C.J. Quinn  Timothy J.C. Bruxner  Angelika N. Christ  Ivon Harliwong  Senel Idrisoglu  Suzanne Manning  Craig Nourse  Ehsan Nourbakhsh  Andrew V. Biankin
Affiliation:1. The Kinghorn Cancer Centre, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia;2. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia;3. Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia;4. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom;5. Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia;6. South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia;7. West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom;8. St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Darlinghurst, New South Wales, Australia;9. Genetic and Molecular Pathology, Adelaide, South Australia, Australia;10. School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia;11. South Eastern Area Laboratory Services Pathology, Prince of Wales Hospital, Randwick, New South Wales, Australia;12. Sonic Genetics, Douglass Hanly Moir Pathology, New South Wales, Australia;13. Macarthur Cancer Therapy Centre, Campbelltown Hospital, New South Wales, Australia;14. Department of Anatomical Pathology, SydPath, St Vincent''s Hospital, New South Wales, Australia;15. School of Environmental and Life Sciences, University of Newcastle, Ourimbah, New South Wales, Australia;16. Department of Surgery, Royal North Shore Hospital, Sydney, New South Wales, Australia;17. University of Sydney, Sydney, New South Wales, Australia;18. Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia;19. School of Medicine, Western Sydney University, Penrith, New South Wales, Australia;20. Department of Surgery, Fiona Stanley Hospital, Murdoch, Washington;21. Department of Gastroenterology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia;22. Department of Surgery, Princess Alexandra Hospital, Woollongabba, Queensland, Australia;23. School of Surgery, University of Western Australia, Australia and St John of God Pathology, Subiaco, Washington;24. Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom;25. Department of Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom;26. Department of Pathology, Southern General Hospital, Greater Glasgow & Clyde National Health Service, Glasgow, United Kingdom;27. Greater Glasgow and Clyde Bio-repository, Pathology Department, Queen Elizabeth University Hospital, Glasgow, United Kingdom;28. Cancer Research UK Beatson Institute, Glasgow, United Kingdom;29. Institute for Cancer Science, University of Glasgow, Glasgow, United Kingdom;30. Universitätsklinikum Erlangen, Erlangen, Germany;31. Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins University School of Medicine, Baltimore, Maryland;32. Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins University School of Medicine, Baltimore, Maryland;33. ARC-NET Center for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy;34. Department of Pathology and Diagnostics, University of Verona, Verona, Italy;35. Department of Medicine, University and Hospital Trust of Verona, Verona, Italy;36. Division of Hematology and Oncology, University of California, San Francisco, California;37. Australian Pancreatic Cancer Genome Initiative;38. Universitätsklinikum Erlangen, Department of Surgery, University of Erlangen-Nueremberg, Germany;39. Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, New South Wales, Australia;40. University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia
Abstract:
Keywords:Pancreatic Adenocarcinoma  Sequencing  Somatic Rearrangement  Cancer Genetics  HR  homologous recombination  Mb  megabase  MMR  mismatch repair  MSI  microsatellite instability  WGS  whole genome sequencing
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