| 肥胖儿童心血管代谢风险相关的预警指标研究进展 |
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| 引用本文： | 韩琰,彭璐婷,李晓南.肥胖儿童心血管代谢风险相关的预警指标研究进展[J].中国儿童保健杂志,2021,29(11):1208-1212. |
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| 作者姓名： | 韩琰 彭璐婷 李晓南 |
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| 作者单位： | 南京医科大学附属儿童医院儿童保健科,江苏 南京 210008 |
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| 基金项目： | 国家自然科学基金(81773421);江苏省重点病种规范化诊疗项目(BE2015607);江苏省科教强卫工程医学创新团队(CXTDA2017035) |
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| 摘 要： | 儿童期肥胖增加血脂异常、高血压、高血糖等心血管代谢风险(CMR),并可持续至成人,使代谢性疾病低龄化。近年发现,尿酸、视黄醇结合蛋白4、维生素D、颈围等与肥胖儿童CMR密切相关,可作为CMR的预警指标,为心血管代谢疾病的早期防治提供新靶标。认识预警指标与代谢风险的关系、作用机制和临床意义,有助于早期识别有CMR相关因素的高危人群并进行干预。
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| 关 键 词： | 儿童肥胖 心血管代谢风险 尿酸 视黄醇结合蛋白4 维生素D 颈围 |
| 收稿时间： | 2020-07-04 |
| 修稿时间： | 2020-09-08 |
Research progress on the indicators of cardiometabolic risk in obese children |
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| HAN Yan,PENG Lu-ting,LI Xiao-nan.Research progress on the indicators of cardiometabolic risk in obese children[J].Chinese Journal of Child Health Care,2021,29(11):1208-1212. |
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| Authors: | HAN Yan PENG Lu-ting LI Xiao-nan |
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| Institution: | Department of Child Health Care,Children′s Hospital of Nanjing Medical University,Nanjing,Jiangsu 210008,China |
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| Abstract: | Childhood obesity increases the cardiometabolic risks (CMR) such as dyslipidemia,hypertension,and hyperglycemia,and usually persists into adulthood,leading to younger age trend of metabolic diseases. At present,a large number of studies have found that uric acid,retinol-binding protein 4,vitamin D and other factors are related to the CMR in obese children,which can be used as a marker of CMR and provide new ideas for the prevention and treatment of cardiovascular metabolic diseases. Therefore,it is of great importance to understand the relationship and mechanism between indicators and CMR,which is beneficial for early identification and intervention of high-risk groups of cardiovascular and metabolic diseases. |
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| Keywords: | childhood obesity cardiometabolic risk uric acid retinol-binding protein 4 vitamin D neck circumference |
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