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| 髓源性抑制细胞在乳腺癌转移中的研究进展 | |
| 引用本文： | 彭心怡,李妍,徐至理,郭勇. 髓源性抑制细胞在乳腺癌转移中的研究进展[J]. 中国医学科学院学报, 2021, 43(3): 445-451. DOI: 10.3881/j.issn.1000-503X.12586 |
| 作者姓名： | 彭心怡 李妍 徐至理 郭勇 |
| 作者单位： | 1.浙江中医药大学第一临床医学院,杭州 310053;2.浙江中医药大学附属第一医院肿瘤科,杭州 310006 |
| 基金项目： | 国家自然科学基金(81973805);浙江省中医药管理局科技计划项目(2015ZA088);“十三五”浙江省中医药(中西医结合)重点学科建设(2017xk-a049) |
| 摘 要： | 乳腺癌患者好发骨、肝和肺转移,预后往往较差。根据Paget提出的“种子与土壤”学说,不同的组织微环境对癌细胞存在不同的吸引。研究表明,髓源性抑制细胞(MDSCs)可提前在乳腺癌转移部位募集,并在乳腺癌细胞多个转移环节中发挥重要作用,其在乳腺癌原发灶之外促进癌细胞转移的作用日益受到重视。本文总结了MDSCs的生物学特性、参与乳腺癌转移的多个环节,包括在外周循环、转移前微环境和转移灶中的促转移机制,以及靶向MDSCs治疗乳腺癌转移的研究进展。 |
| 关 键 词： | 髓源性抑制细胞 乳腺癌 转移 肿瘤微环境 |
| 收稿时间： | 2020-02-07 |
Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis |
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| PENG Xinyi,LI Yan,XU Zhili,GUO Yong. Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis[J]. Acta Academiae Medicinae Sinicae, 2021, 43(3): 445-451. DOI: 10.3881/j.issn.1000-503X.12586 | |
| Authors: | PENG Xinyi LI Yan XU Zhili GUO Yong |
| Affiliation: | 1.The First Clinical College of Zhejiang Chinese Medical University,Hangzhou 310053,China;2.Department of Oncology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China |
| Abstract: | Breast cancer patients with bone,liver and lung metastases tend to have a poor prognosis.According to Paget’s “seed and soil” theory,metastatic cancer cell “seeds” must fall on congenial target organ “soil”.Studies have shown that myeloid-derived suppressor cells(MDSCs)can be recruited at the site of breast cancer metastasis in advance and play a role in the metastasis of breast cancer cells.This paper reviews the biological characteristics of MDSCs,the roles of MDSCs in peripheral circulation,prometastatic niche,and metastatic site during breast cancer metastasis,as well as the research progress of MDSCs-targeted treatment of breast cancer metastasis. |
| Keywords: | myeloid-derived suppressor cells breast cancer metastasis tumor microenvironment |
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