线粒体通透性转换孔在脑缺血再灌注损伤中的研究进展

缺血性脑血管疾病是威胁人类健康的主要疾病之一，尽早恢复脑组织的供血供氧是挽救患者生命、降低致残率的有效手段，但脑组织恢复血氧供应后，却有可能发生更严重的损伤，即脑缺血再灌注损伤（ischemiareperfusioninjury，I/R）。线粒体作为能量产生的重要细胞器，对神经元的存活极为重要。在线粒体功能障碍的众多潜在机制中，线粒体通透性转换孔（mitochondrial permeability transition pore，mPTP）的开放是近年来越来越受关注的机制之一，mPTP是介导脑功能障碍和细胞死亡的关键节点，该文系统地综述mPTP和I/R的研究现状，以期为临床治疗脑缺血/再灌注损伤提供一个新的治疗思路。

Research Progress of Mitochondrial Permeability Transition Pore in Cerebral Ischemia-Reperfusion Injury

Ischemic cerebrovascular disease is one of the main diseases threatening human health. Restoring blood and oxygen supply to brain tissue as soon as possible is an effective means to save patients’ lives and reduce disability rate. However，after restoring blood and oxygen supply to brain tissue，more serious injury may occur，namely cerebral ischemiareperfusion injury（I/R）. As an important organelle for energy production，mitochondria are very important for the survival of neurons. Among the many potential mechanisms of mitochondrial dysfunction，the opening of mitochondrial permeability transition pore（mPTP） has attracted more and more attention in recent years. mPTP is a key node mediating brain dysfunction and cell death. This paper systematically summarizes the research status of mitochondrial permeability transition pore and cerebral ischemia-reperfusion injury in order to provide a new treatment idea for clinical treatment of cerebral ischemia-reperfusion injury.