散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症的疗效和安全性

 目的 探讨散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症(endometriosis,EMT)的疗效和安全性。方法 选取2013-12至2017-05在应急总医院和武警北京总队医院妇科就诊的轻型EMT患者90例,均无手术指征,按照随机数字表法分为研究组和对照组,每组45例。研究组于月经第1天开始口服散结镇痛胶囊1.6 g,3次/d,连续服用6个月;同时于月经第1天开始口服去氧孕烯炔雌醇片1片/d,连服21 d,停药第8天开始新的周期,共6个月。对照组给予去氧孕烯炔雌醇片,方法、剂量同研究组。患者治疗前、后行妇科检查、视觉模拟评分法(VAS)评分、妇科超声、心电图、肝肾功能、凝血功能、CA125检查。结果 研究组治愈率(73.3%)和总有效率(97.8%)均高于对照组(治愈率31.1%,总有效率82.2%),差异均有统计学意义(P<0.05);治疗后VAS评分研究组(1.9±1.1)分]明显低于对照组(2.7±1.8)分],差异有统计学意义(P<0.05);治疗后血清CA125研究组(19.62±11.13)U/ml]明显低于对照组(24.78±13.21)U/ml],差异有统计学意义(P<0.05)。结论 散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症安全有效。

Clinical study on combined Sanjie Zhentong capsule and desogestrel and ethlinylestradiol tablets in treatment of mild endometriosis

Objective This research aims to investigate the efficacy and safety of the Sanjie Zhentong capsule combined with desogestrel and ethinylestradiol tablets in the treatment of mild endometriosis.Methods From December 2013 to May 2017, in China Emergency General Hospital and Beijing Municipal Corps Hospital of Chinese People's Armed Police Force, a total of 90 patients with mild endometriosis without surgical indications were randomly allocated into either the Study Group (n=45) or the Control Group (n=45). The study group took Sanjie Zhentong capsules orally from the first day of menstruation, 1.6g each and three times per day. Simultaneously, one desogestrel and ethinylestradiol tablet was taken orally in the evening from the first day of menstruation for 21 days. A new cycle was started on the eighth day of withdrawal.The research lasted for six consecutive months. The control group was given only desogestrel ethinylestradiol tablets, and the method was the same as that of the study group. The patients were examined before and after treatment, including gynecological examination, visual analogue scale (VAS) score, B ultrasound, electrocardiogram, liver and kidney function, coagulation function, and CA125.Results The cure rate of the study group was 73.3%, and that of the control group was 31.1%, the difference was statistically significant (P< 0.05); The total effective rate of the study group was 97.8%, and that of the control group was 82.2%, the difference was statistically significant (P< 0.05); The score of VAS in the study group was (1.9±1.1) and that of in control group was (2.7±1.8) after treatment, the difference was statistically significant (P< 0.05); The value of serum CA125 in the study group was (19.62±11.13)U/ml, and that of in control group was (24.78±13.21)U/ml, the difference was statistically significant (P<0.05).Conclusions Sanjie Zhentong capsule combined with desogestrel and ethinylestradiol tablets is safe and effective in treating mild endometriosis.